Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses

Sari E. Lauri; Caroline Delany; Vernon R.J. Clarke; Zuner A. Bortolotto; Paul L. Ornstein; John Isaac; Graham L. Collingridge

doi:10.1016/S0028-3908(01)00152-6

Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses

Sari E. Lauri, Caroline Delany, Vernon R.J. Clarke, Zuner A. Bortolotto, Paul L. Ornstein, John Isaac, Graham L. Collingridge^*

^*Corresponding author for this work

Neuroscience

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

The development of GluR5-selective kainate receptor ligands is helping to elucidate the functions of kainate receptors in the CNS. Here we have further characterised the actions of a GluR5 selective agonist, ATPA, and a GluR5 selective antagonist, LY382884, in the CA3 region of rat hippocampal slices. In addition, we have used LY382884 to study a novel synaptic mechanism. This antagonist substantially reduces frequency facilitation of mossy fibre synaptic transmission, monitored as either AMPA or NMDA receptor-mediated EPSCs. This suggests that GluR5-containing kainate receptors on mossy fibres function as autoreceptors to facilitate the synaptic release of L-glutamate, in a frequency-dependent manner.

Original language	English (US)
Pages (from-to)	907-915
Number of pages	9
Journal	Neuropharmacology
Volume	41
Issue number	8
DOIs	https://doi.org/10.1016/S0028-3908(01)00152-6
State	Published - 2001

Funding

Supported by the MRC and The Wellcome Trust. We are grateful to Bill Anderson for providing the data analysis software.

Keywords

APTA
Autoreceptor
Hippocampus
Kainate receptor
LY382884
Mossy fibres

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

Access to Document

10.1016/S0028-3908(01)00152-6

Cite this

@article{e9076d96298945f99eb23626aafba6de,

title = "Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses",

abstract = "The development of GluR5-selective kainate receptor ligands is helping to elucidate the functions of kainate receptors in the CNS. Here we have further characterised the actions of a GluR5 selective agonist, ATPA, and a GluR5 selective antagonist, LY382884, in the CA3 region of rat hippocampal slices. In addition, we have used LY382884 to study a novel synaptic mechanism. This antagonist substantially reduces frequency facilitation of mossy fibre synaptic transmission, monitored as either AMPA or NMDA receptor-mediated EPSCs. This suggests that GluR5-containing kainate receptors on mossy fibres function as autoreceptors to facilitate the synaptic release of L-glutamate, in a frequency-dependent manner.",

keywords = "APTA, Autoreceptor, Hippocampus, Kainate receptor, LY382884, Mossy fibres",

author = "Lauri, {Sari E.} and Caroline Delany and Clarke, {Vernon R.J.} and Bortolotto, {Zuner A.} and Ornstein, {Paul L.} and John Isaac and Collingridge, {Graham L.}",

note = "Funding Information: Supported by the MRC and The Wellcome Trust. We are grateful to Bill Anderson for providing the data analysis software. ",

year = "2001",

doi = "10.1016/S0028-3908(01)00152-6",

language = "English (US)",

volume = "41",

pages = "907--915",

journal = "Neuropharmacology",

issn = "0028-3908",

publisher = "Elsevier Limited",

number = "8",

}

TY - JOUR

T1 - Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses

AU - Lauri, Sari E.

AU - Delany, Caroline

AU - Clarke, Vernon R.J.

AU - Bortolotto, Zuner A.

AU - Ornstein, Paul L.

AU - Isaac, John

AU - Collingridge, Graham L.

N1 - Funding Information: Supported by the MRC and The Wellcome Trust. We are grateful to Bill Anderson for providing the data analysis software.

PY - 2001

Y1 - 2001

N2 - The development of GluR5-selective kainate receptor ligands is helping to elucidate the functions of kainate receptors in the CNS. Here we have further characterised the actions of a GluR5 selective agonist, ATPA, and a GluR5 selective antagonist, LY382884, in the CA3 region of rat hippocampal slices. In addition, we have used LY382884 to study a novel synaptic mechanism. This antagonist substantially reduces frequency facilitation of mossy fibre synaptic transmission, monitored as either AMPA or NMDA receptor-mediated EPSCs. This suggests that GluR5-containing kainate receptors on mossy fibres function as autoreceptors to facilitate the synaptic release of L-glutamate, in a frequency-dependent manner.

AB - The development of GluR5-selective kainate receptor ligands is helping to elucidate the functions of kainate receptors in the CNS. Here we have further characterised the actions of a GluR5 selective agonist, ATPA, and a GluR5 selective antagonist, LY382884, in the CA3 region of rat hippocampal slices. In addition, we have used LY382884 to study a novel synaptic mechanism. This antagonist substantially reduces frequency facilitation of mossy fibre synaptic transmission, monitored as either AMPA or NMDA receptor-mediated EPSCs. This suggests that GluR5-containing kainate receptors on mossy fibres function as autoreceptors to facilitate the synaptic release of L-glutamate, in a frequency-dependent manner.

KW - APTA

KW - Autoreceptor

KW - Hippocampus

KW - Kainate receptor

KW - LY382884

KW - Mossy fibres

UR - http://www.scopus.com/inward/record.url?scp=0035669128&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035669128&partnerID=8YFLogxK

U2 - 10.1016/S0028-3908(01)00152-6

DO - 10.1016/S0028-3908(01)00152-6

M3 - Article

C2 - 11747895

AN - SCOPUS:0035669128

SN - 0028-3908

VL - 41

SP - 907

EP - 915

JO - Neuropharmacology

JF - Neuropharmacology

IS - 8

ER -

Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this