Synchronous and Metastatic Papillary and Follicular Thyroid Carcinomas with Unique Molecular Signatures

Vincent Cracolici*, Ibro Mujacic, Sabah Kadri, Mir Alikhan, Nifang Niu, Jeremy P. Segal, Lauren E. Rosen, David H. Sarne, Adam Morgan, Samy Desouky, Nicole A. Cipriani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Despite the relatively high prevalence of thyroid cancer, the occurrence of multiple synchronous, distinct subtypes of primary thyroid carcinoma is uncommon. The incidental finding of papillary thyroid microcarcinoma in a gland with a biologically relevant follicular or medullary carcinoma is more frequent than the synchronous occurrence of multiple clinically significant carcinomas. We report a case of synchronous papillary and follicular thyroid carcinomas metastatic to lymph node and bone, respectively. Next generation sequencing showed BRAF V600E mutation in the primary papillary carcinoma and NRAS Q61R mutation in the primary follicular carcinoma and bony metastasis. To our knowledge, this is the first reported case of synchronous and metastatic primary papillary and follicular carcinomas, and the first report of synchronous BRAF V600E mutated papillary and NRAS mutated follicular carcinoma.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalEndocrine Pathology
Volume29
Issue number1
DOIs
StatePublished - Mar 1 2018

Keywords

  • Follicular thyroid carcinoma
  • Metastatic thyroid carcinoma
  • Molecular signatures of thyroid carcinoma
  • Papillary thyroid carcinoma
  • Synchronous thyroid carcinomas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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