Synchronous breast cancer and alveolar rhabdomyosarcoma bone marrow metastases

Ami Shah, Jonathon Weber*, Angelique Floerke, Luis Blanco, Cesar Santa-Maria, Mark Aguinik, Sonya Bhole

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Alveolar rhabdomyosarcoma (RMS) is primarily a malignancy of childhood and adolescence. While RMS is rare in adults, the breast and the bone marrow are known but uncommon sites for metastatic disease. Bone marrow is also a known sanctuary site for metastatic breast cancer. We present the case of a woman with a remote history of breast cancer and RMS who developed anemia and thrombocytopenia of unknown etiology. Additional laboratory tests were negative for a cause; therefore, the decision was made to proceed with a bone marrow biopsy. The initial biopsy results were consistent with breast cancer metastasis. Subsequent diagnostic imaging of the breast led to biopsy of an enlarging morphologically benign breast mass, unexpectedly yielding alveolar RMS. This unanticipated diagnosis led to revaluation of the bone marrow, this time showing synchronous metastases from breast carcinoma and alveolar RMS. Imaging findings of this patient, along with literature review of RMS imaging characteristics, will be reviewed.

Original languageEnglish (US)
Pages (from-to)680-684
Number of pages5
JournalRadiology Case Reports
Issue number3
StatePublished - Jun 2018


  • Alveolar rhabdomyosarcoma
  • Bone marrow carcinomatosis
  • Bone metastases
  • Breast cancer
  • Synchronous

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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