Synchrony and entrainment properties of robust circadian oscillators

Neda Bagheri, Stephanie R. Taylor, Kirsten Meeker, Linda R. Petzold, Francis J. Doyle

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Systems theoretic tools (i.e. mathematical modelling, control, and feedback design) advance the understanding of robust performance in complex biological networks. We highlight phase entrainment as a key performance measure used to investigate dynamics of a single deterministic circadian oscillator for the purpose of generating insight into the behaviour of a population of (synchronized) oscillators. More specifically, the analysis of phase characteristics may facilitate the identification of appropriate coupling mechanisms for the ensemble of noisy (stochastic) circadian clocks. Phase also serves as a critical control objective to correct mismatch between the biological clock and its environment. Thus, we introduce methods of investigating synchrony and entrainment in both stochastic and deterministic frameworks, and as a property of a single oscillator or population of coupled oscillators.

Original languageEnglish (US)
Pages (from-to)S17-S28
JournalJournal of the Royal Society Interface
Issue numberSUPPL. 1
StatePublished - Aug 6 2008


  • Circadian clocks
  • Control
  • Coupled oscillators
  • Phase response curves
  • Stochastic simulations

ASJC Scopus subject areas

  • Bioengineering
  • Biophysics
  • Biochemistry
  • Biotechnology
  • Biomedical Engineering
  • Biomaterials


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