Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro

Zuo Hui Shao, Terry L. Vanden Hoek, Chang Qing Li, Paul T. Schumacker, Lance B. Becker, Kim Chan Chan, Yimin Qin, Jun Jie Yin, Chun Su Yuan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Scutellaria baicalensis (SbE) is a commonly used Chinese herb medicine and grape seed proanthocyanidins is a popular herbal supplement in the United States. Both herbs have been shown to possess potent antioxidant effects. Using an in vitro model to produce the reactive oxygen species (ROS) generation (H2O2/FeSO4 for hydroxyl radicals, xanthine/xanthine oxidase for suproxide), we observed that Scutellaria baicalensis and grape seed proanthocyanidins acted synergistically to scavenge ROS. Our data suggest that a combination of these two herbs can potentially enhance their antioxidant efficacy, allowing lower dosages of each drug to be used. This has the advantage of avoiding possible side effects that may arise when higher doses of a single herb are used in an attempt to achieve a maximum degree of antioxidant activity.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalAmerican Journal of Chinese Medicine
Volume32
Issue number1
DOIs
StatePublished - 2004

Keywords

  • Antioxidant
  • Grape seed proanthocyanidins
  • Herbal medicine
  • Hydroxyl radicals
  • Scutellaria baicalensis
  • Suproxide
  • Synergistic effect

ASJC Scopus subject areas

  • Complementary and alternative medicine

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