Synovial fluid in seronegative juvenile rheumatoid arthritis

Christina L. Martin, Lauren M Pachman*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Synovial fluid of 20 children with seronegative juvenile rheumatoid arthritis (JRA) and 20 patients with other joint pathology was examined for levels of total hemolytic complement and selected components, immune complexes, and α2‐macroglobulin (α2‐M). When adjusted for total protein, synovial levels of total hemolytic complement, C3, C4, and α2‐M did not differ significantly in the two groups. The concentrations of IgM and IgG were elevated in the JRA synovial fluid, but immune complexes were not increased when compared with the non‐JRA group as determined by the Raji cell technique. α2‐M activity against substrates of C1 esterase was absent. Therefore, evidence of specific increase in immune complexes and complement activation was sought but not found, suggesting that they may not be a major factor in the pathogonesis of seronegative, pauciarticular JRA.

Original languageEnglish (US)
Pages (from-to)1256-1261
Number of pages6
JournalArthritis & Rheumatism
Volume23
Issue number11
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Synovial fluid in seronegative juvenile rheumatoid arthritis'. Together they form a unique fingerprint.

  • Cite this