Synovial sarcoma presenting as a lung mass and diagnosed by cytology

Alexander D. Pyden, Xiaoqi Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Synovial sarcoma is a common soft tissue sarcoma with variable fibrous and epithelial differentiation that rarely arises from other body sites, such as within the lung. A case of a 68-year-old male with an extensive smoking history who presented with chest pain and a primary, central, metabolically active lung mass was reported. The mass was biopsied by bronchial brushing, bronchoalveolar lavage (BAL), and transbronchial fine-needle aspiration (FNA). Cytologic analysis of bronchial brushing, BAL, and FNA revealed single and clusters of atypical spindle cells, oval, or spindle-shaped nuclei with smooth nuclear membranes, hyperchromatic and granular chromatin, scant to moderate and delicate cytoplasm, a high degree of mitotic figures, and a lack of necrosis. Immunohistochemical studies showed that the tumor cells were positive for CD99, BCL2, and CK7. A diagnosis of synovial sarcoma was rendered. The differential diagnosis of primary pulmonary synovial sarcoma is discussed, including neuroendocrine tumors, squamous cell carcinoma, and various sarcomatous tumors.

Original languageEnglish (US)
Pages (from-to)434-437
Number of pages4
JournalDiagnostic cytopathology
Issue number5
StatePublished - May 1 2016


  • bronchial brushing
  • bronchoalveolar lavage
  • fine needle aspiration
  • immunohistochemistry
  • synovial sarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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