@article{cdcfc1c17cc74d5f804005ef0705a568,
title = "Syntheses of three-dimensional catenanes under kinetic control",
abstract = "Although catenanes comprising two ring-shaped components can be made in large quantities by templation, the preparation of three-dimensional (3D) catenanes with cage-shaped components is still in its infancy. Here, we report the design and syntheses of two 3D catenanes by a sequence of SN2 reactions in one pot. The resulting triply mechanically interlocked molecules were fully characterized in both the solution and solid states. Mechanistic studies have revealed that a suit[3]ane, which contains a threefold symmetric cage component as the suit and a tribromide component as the body, is formed at elevated temperatures. This suit[3]ane was identified as the key reactive intermediate for the selective formation of the two 3D catenanes which do not represent thermodynamic minima. We foresee a future in which this particular synthetic strategy guides the rational design and production of mechanically interlocked molecules under kinetic control.",
keywords = "Cationic cages, Mechanically interlocked molecules, Nontrivial topologies, Suitanes, Triple [π...π] interactions",
author = "Yong Wu and Guo, {Qing Hui} and Yunyan Qiu and Weber, {Jacob A.} and Young, {Ryan M.} and Laura Bancroft and Yang Jiao and Hongliang Chen and Bo Song and Wenqi Liu and Yuanning Feng and Xingang Zhao and Xuesong Li and Long Zhang and Chen, {Xiao Yang} and Hao Li and Wasielewski, {Michael R.} and Stoddart, {J. Fraser}",
note = "Funding Information: ACKNOWLEDGMENTS. Financial support from Northwestern University (NU) is gratefully acknowledged. This work was supported by the National Science Foundation (DMR-2003739 to M.R.W.) and the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study (SN-ZJU-SIAS-006 to H.L., Q.-H.G., and H.C.). Q.-H.G. and H.C. thank ZJU-Hangzhou Global Scientific and Technological Innovation Center for generous startup funding. Q.-H.G. thanks the National Natural Science Foundation of China (22193020 and 22193022). This work made use of the IMSERC at NU, which receives support from the National Institutes of Health (1S10OD012016-01/1S10RR019071-01A1), Soft and Hybrid Nanotechnology Experimental Resource (NSF ECCS-1542205), the state of Illinois, and the International Institute for Nanotechnology. We thank Dr. Yang Yu at NU for assistance in HPLC experiments. Funding Information: Financial support from Northwestern University (NU) is gratefully acknowledged. This work was supported by the National Science Foundation (DMR-2003739 to M.R.W.) and the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study (SN-ZJU-SIAS-006 to H.L., Q.-H.G., and H.C.). Q.-H.G. and H.C. thank ZJU-Hangzhou Global Scientific and Technological Innovation Center for generous startup funding. Q.-H.G. thanks the National Natural Science Foundation of China (22193020 and 22193022). This work made use of the IMSERC at NU, which receives support from the National Institutes of Health (1S10OD012016-01/1S10RR019071-01A1), Soft and Hybrid Nanotechnology Experimental Resource (NSF ECCS-1542205), the state of Illinois, and the International Institute for Nanotechnology. We thank Dr. Yang Yu at NU for assistance in HPLC experiments. Publisher Copyright: Copyright {\textcopyright} 2022 the Author(s).",
year = "2022",
month = mar,
day = "22",
doi = "10.1073/pnas.2118573119",
language = "English (US)",
volume = "119",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "12",
}