Synthesis and antitumor activities of 3-substituted 1-(5-formylfurfuryl)indolin-2-one derivatives

Fusheng Zhou, Jianbin Zheng, Xiaochun Dong, Zhiwen Zhang, Lingling Zhao, Xianyi Sha, Lin Li, Ren Wen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Forty-two 3-substituted 1-(5-formylfurfuryl)indolin-2-ones were synthesized and most of these compounds exhibited potent inhibitory activities against P. oryzae (MIC = 0.78-25 μg/mL) and human intestinal Caco-2 cells (IC50 = 0.19-9.42 μM). Eight compounds selected for further screening also showed inhibitory activities (IC50 = 1.84-10.32 μM) against human lung adenocarcinoma cells (SPC-A1).

Original languageEnglish (US)
Pages (from-to)601-605
Number of pages5
JournalLetters in Organic Chemistry
Issue number8
StatePublished - Dec 2007


  • 3-substituted 1-(5-formylfurfuryl)indolin-2-ones
  • Antifungal activity
  • Antitumor activity
  • Caco-2 cells
  • Pyricoraria oryzae
  • SPC-A1

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry


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