Synthesis and biological evaluation of myoseverin derivatives: Microtubule assembly inhibitors

Y. T. Chang*, S. M. Wignall, G. R. Rosania, N. S. Gray, S. R. Hanson, A. I. Su, Jr Merlie, H. S. Moon, S. B. Sangankar, O. Perez, R. Heald, P. G. Schultz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Myoseverin, a trisubstituted purine, inhibits microtubule assembly in vitro, interferes with normal mitotic spindle assembly, and arrests the cell cycle in mitosis in U937 cells. We synthesized a variety of myoseverin derivatives and screened them for inhibition of spindle assembly in Xenopus egg extracts and for microtubule disassembly in vitro. Selected compounds were tested against 60 cancer cell lines at the National Cancer Institute as possible anticancer drug candidates.

Original languageEnglish (US)
Pages (from-to)4497-4500
Number of pages4
JournalJournal of Medicinal Chemistry
Volume44
Issue number26
DOIs
StatePublished - Dec 20 2001

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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