Abstract
Myoseverin, a trisubstituted purine, inhibits microtubule assembly in vitro, interferes with normal mitotic spindle assembly, and arrests the cell cycle in mitosis in U937 cells. We synthesized a variety of myoseverin derivatives and screened them for inhibition of spindle assembly in Xenopus egg extracts and for microtubule disassembly in vitro. Selected compounds were tested against 60 cancer cell lines at the National Cancer Institute as possible anticancer drug candidates.
Original language | English (US) |
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Pages (from-to) | 4497-4500 |
Number of pages | 4 |
Journal | Journal of Medicinal Chemistry |
Volume | 44 |
Issue number | 26 |
DOIs | |
State | Published - Dec 20 2001 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery