Abstract
A series of noscapine analogues have been synthesized via 13-step reaction starting from 2-hydroxy-3-methoxybenzaldehyde. Anti-tumor activities of these compounds were evaluated against HL-60 cell lines in vitro by the standard MTT assay. It was found that most of these derivatives showed appreciable inhibitory activity against HL-60 and tubulin polymerization. The results also indicated that the potency of compound 31 is about three times more than that of noscapine against HL-60 cell line and tubulin polymerization. Moreover, it induced a massive accumulation of cells in G2/M phase. These results showed noscapine and its derivatives were worth to be intensively studied further.
Original language | English (US) |
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Pages (from-to) | 1347-1357 |
Number of pages | 11 |
Journal | Yaoxue Xuebao |
Volume | 47 |
Issue number | 10 |
State | Published - Oct 12 2012 |
Keywords
- Cytotoxic activity
- Microtubule-interfering agent
- Noscapine
- Tubulin
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)