Synthesis and biological evaluation of noscapine analogues as microtubule-interfering agents

Hou Ling Dai, Jian Bin Zheng*, Min Lin, Jing Zheng, Fu Sheng Zhou, Xiao Chun Dong, Lei Guo, Jian Wen Liu, Ren Wen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A series of noscapine analogues have been synthesized via 13-step reaction starting from 2-hydroxy-3-methoxybenzaldehyde. Anti-tumor activities of these compounds were evaluated against HL-60 cell lines in vitro by the standard MTT assay. It was found that most of these derivatives showed appreciable inhibitory activity against HL-60 and tubulin polymerization. The results also indicated that the potency of compound 31 is about three times more than that of noscapine against HL-60 cell line and tubulin polymerization. Moreover, it induced a massive accumulation of cells in G2/M phase. These results showed noscapine and its derivatives were worth to be intensively studied further.

Original languageEnglish (US)
Pages (from-to)1347-1357
Number of pages11
JournalYaoxue Xuebao
Volume47
Issue number10
StatePublished - Oct 12 2012

Keywords

  • Cytotoxic activity
  • Microtubule-interfering agent
  • Noscapine
  • Tubulin

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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