Synthesis and biological evaluation of novel indolin-2-one derivatives as protein tyrosine phosphatase 1b inhibitors

Hou Ling Dai, Qiang Shen, Jian Bin Zheng*, Jing Ya Lib, Ren Wen, Jia Li

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

3-Substituted indolin-2-one derivatives had been designed and synthesized as a novel class ofprotein tyrosine phosphatase 1B (PTP1B) inhibitors. These compounds had been evaluated for their inhibitory activities against PTP1B in vitro with IC50 values in a low micromolar range.Compound 36, the lowest, bore an IC50 value of 3.48 μM. Preliminary structure-activity relationship was summarized.

Original languageEnglish (US)
Pages (from-to)526-530
Number of pages5
JournalLetters in Organic Chemistry
Volume8
Issue number7
DOIs
StatePublished - Sep 1 2011

Keywords

  • 3-substituted indolin-2-ones
  • Diabetes
  • Inhibitor
  • Protein tyrosine phosphatase 1B
  • Structure-activity relationship

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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