Synthesis and biological evaluation of novel indolin-2-one derivatives as protein tyrosine phosphatase 1b inhibitors

Hou Ling Dai; Qiang Shen; Jian Bin Zheng; Jing Ya Lib; Ren Wen; Jia Li

doi:10.2174/157017811796504909

Synthesis and biological evaluation of novel indolin-2-one derivatives as protein tyrosine phosphatase 1b inhibitors

Hou Ling Dai, Qiang Shen, Jian Bin Zheng^*, Jing Ya Lib, Ren Wen, Jia Li

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

3-Substituted indolin-2-one derivatives had been designed and synthesized as a novel class ofprotein tyrosine phosphatase 1B (PTP1B) inhibitors. These compounds had been evaluated for their inhibitory activities against PTP1B in vitro with IC₅₀ values in a low micromolar range.Compound 36, the lowest, bore an IC₅₀ value of 3.48 μM. Preliminary structure-activity relationship was summarized.

Original language	English (US)
Pages (from-to)	526-530
Number of pages	5
Journal	Letters in Organic Chemistry
Volume	8
Issue number	7
DOIs	https://doi.org/10.2174/157017811796504909
State	Published - Sep 2011

Keywords

3-substituted indolin-2-ones
Diabetes
Inhibitor
Protein tyrosine phosphatase 1B
Structure-activity relationship

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/157017811796504909

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title = "Synthesis and biological evaluation of novel indolin-2-one derivatives as protein tyrosine phosphatase 1b inhibitors",

abstract = "3-Substituted indolin-2-one derivatives had been designed and synthesized as a novel class ofprotein tyrosine phosphatase 1B (PTP1B) inhibitors. These compounds had been evaluated for their inhibitory activities against PTP1B in vitro with IC50 values in a low micromolar range.Compound 36, the lowest, bore an IC50 value of 3.48 μM. Preliminary structure-activity relationship was summarized.",

keywords = "3-substituted indolin-2-ones, Diabetes, Inhibitor, Protein tyrosine phosphatase 1B, Structure-activity relationship",

author = "Dai, {Hou Ling} and Qiang Shen and Zheng, {Jian Bin} and Lib, {Jing Ya} and Ren Wen and Jia Li",

year = "2011",

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doi = "10.2174/157017811796504909",

language = "English (US)",

volume = "8",

pages = "526--530",

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TY - JOUR

T1 - Synthesis and biological evaluation of novel indolin-2-one derivatives as protein tyrosine phosphatase 1b inhibitors

AU - Dai, Hou Ling

AU - Shen, Qiang

AU - Zheng, Jian Bin

AU - Lib, Jing Ya

AU - Wen, Ren

AU - Li, Jia

PY - 2011/9

Y1 - 2011/9

N2 - 3-Substituted indolin-2-one derivatives had been designed and synthesized as a novel class ofprotein tyrosine phosphatase 1B (PTP1B) inhibitors. These compounds had been evaluated for their inhibitory activities against PTP1B in vitro with IC50 values in a low micromolar range.Compound 36, the lowest, bore an IC50 value of 3.48 μM. Preliminary structure-activity relationship was summarized.

AB - 3-Substituted indolin-2-one derivatives had been designed and synthesized as a novel class ofprotein tyrosine phosphatase 1B (PTP1B) inhibitors. These compounds had been evaluated for their inhibitory activities against PTP1B in vitro with IC50 values in a low micromolar range.Compound 36, the lowest, bore an IC50 value of 3.48 μM. Preliminary structure-activity relationship was summarized.

KW - 3-substituted indolin-2-ones

KW - Diabetes

KW - Inhibitor

KW - Protein tyrosine phosphatase 1B

KW - Structure-activity relationship

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DO - 10.2174/157017811796504909

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EP - 530

JO - Letters in Organic Chemistry

JF - Letters in Organic Chemistry

IS - 7

ER -

Synthesis and biological evaluation of novel indolin-2-one derivatives as protein tyrosine phosphatase 1b inhibitors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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