3-Substituted indolin-2-one derivatives had been designed and synthesized as a novel class ofprotein tyrosine phosphatase 1B (PTP1B) inhibitors. These compounds had been evaluated for their inhibitory activities against PTP1B in vitro with IC50 values in a low micromolar range.Compound 36, the lowest, bore an IC50 value of 3.48 μM. Preliminary structure-activity relationship was summarized.
- 3-substituted indolin-2-ones
- Protein tyrosine phosphatase 1B
- Structure-activity relationship
ASJC Scopus subject areas
- Organic Chemistry