Synthesis and biological evaluation of p‐bromospiperone as potential neuroleptic drug

C. C. Huang; A. M. Friedman; R. So; M. Simonovic; H. Y. Meltzer

doi:10.1002/jps.2600690835

Synthesis and biological evaluation of p‐bromospiperone as potential neuroleptic drug

C. C. Huang^*, A. M. Friedman, R. So, M. Simonovic, H. Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

p‐Bromospiperone was prepared from the reaction of spiperone with bromine. It was tested for dopamine receptor binding affinity in vitro and its ability to stimulate prolactin secretion in vivo. The results indicate no significant change of biological activities due to the bromination of spiperone.

Original language	English (US)
Pages (from-to)	984-986
Number of pages	3
Journal	Journal of Pharmaceutical Sciences
Volume	69
Issue number	8
DOIs	https://doi.org/10.1002/jps.2600690835
State	Published - Aug 1980

Keywords

Neuroleptics, potential—p‐bromospiperone, synthesis and biological evaluation
Prolactin secretion—stimulation by p‐bromospiperone
Spiperone—p‐bromo analog, synthesis and biological evaluation as a potential neuroleptic

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600690835

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abstract = "p‐Bromospiperone was prepared from the reaction of spiperone with bromine. It was tested for dopamine receptor binding affinity in vitro and its ability to stimulate prolactin secretion in vivo. The results indicate no significant change of biological activities due to the bromination of spiperone.",

keywords = "Neuroleptics, potential—p‐bromospiperone, synthesis and biological evaluation, Prolactin secretion—stimulation by p‐bromospiperone, Spiperone—p‐bromo analog, synthesis and biological evaluation as a potential neuroleptic",

author = "Huang, {C. C.} and Friedman, {A. M.} and R. So and M. Simonovic and Meltzer, {H. Y.}",

year = "1980",

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AU - Friedman, A. M.

AU - So, R.

AU - Simonovic, M.

AU - Meltzer, H. Y.

PY - 1980/8

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Synthesis and biological evaluation of p‐bromospiperone as potential neuroleptic drug

Abstract

Keywords

ASJC Scopus subject areas

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