p‐Bromospiperone was prepared from the reaction of spiperone with bromine. It was tested for dopamine receptor binding affinity in vitro and its ability to stimulate prolactin secretion in vivo. The results indicate no significant change of biological activities due to the bromination of spiperone.
- Neuroleptics, potential—p‐bromospiperone, synthesis and biological evaluation
- Prolactin secretion—stimulation by p‐bromospiperone
- Spiperone—p‐bromo analog, synthesis and biological evaluation as a potential neuroleptic
ASJC Scopus subject areas
- Pharmaceutical Science