Synthesis and biological evaluation of p‐bromospiperone as potential neuroleptic drug

C. C. Huang*, A. M. Friedman, R. So, M. Simonovic, H. Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

p‐Bromospiperone was prepared from the reaction of spiperone with bromine. It was tested for dopamine receptor binding affinity in vitro and its ability to stimulate prolactin secretion in vivo. The results indicate no significant change of biological activities due to the bromination of spiperone.

Original languageEnglish (US)
Pages (from-to)984-986
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume69
Issue number8
DOIs
StatePublished - Aug 1980

Keywords

  • Neuroleptics, potential—p‐bromospiperone, synthesis and biological evaluation
  • Prolactin secretion—stimulation by p‐bromospiperone
  • Spiperone—p‐bromo analog, synthesis and biological evaluation as a potential neuroleptic

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint

Dive into the research topics of 'Synthesis and biological evaluation of p‐bromospiperone as potential neuroleptic drug'. Together they form a unique fingerprint.

Cite this