Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: A new approach toward prodrug-procontrast complexes

Luca Frullano, Baudilio Tejerina, Thomas J. Meade*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

We have prepared the first MRI prodrug-procontrast complex by conjugating doxorubicin to a Gd(III) chelate using an acid-labile linker. The relaxometric properties of the adduct and pH activation are reported.

Original languageEnglish (US)
Pages (from-to)8489-8491
Number of pages3
JournalInorganic chemistry
Volume45
Issue number21
DOIs
StatePublished - Oct 16 2006

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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