Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: A new approach toward prodrug-procontrast complexes

Luca Frullano; Baudilio Tejerina; Thomas J. Meade

doi:10.1021/ic0612045

Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: A new approach toward prodrug-procontrast complexes

Luca Frullano, Baudilio Tejerina, Thomas J. Meade^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

We have prepared the first MRI prodrug-procontrast complex by conjugating doxorubicin to a Gd(III) chelate using an acid-labile linker. The relaxometric properties of the adduct and pH activation are reported.

Original language	English (US)
Pages (from-to)	8489-8491
Number of pages	3
Journal	Inorganic chemistry
Volume	45
Issue number	21
DOIs	https://doi.org/10.1021/ic0612045
State	Published - Oct 16 2006

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry

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10.1021/ic0612045

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title = "Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: A new approach toward prodrug-procontrast complexes",

abstract = "We have prepared the first MRI prodrug-procontrast complex by conjugating doxorubicin to a Gd(III) chelate using an acid-labile linker. The relaxometric properties of the adduct and pH activation are reported.",

author = "Luca Frullano and Baudilio Tejerina and Meade, {Thomas J.}",

year = "2006",

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doi = "10.1021/ic0612045",

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journal = "Inorganic Chemistry",

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T1 - Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate

T2 - A new approach toward prodrug-procontrast complexes

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AU - Tejerina, Baudilio

AU - Meade, Thomas J.

PY - 2006/10/16

Y1 - 2006/10/16

N2 - We have prepared the first MRI prodrug-procontrast complex by conjugating doxorubicin to a Gd(III) chelate using an acid-labile linker. The relaxometric properties of the adduct and pH activation are reported.

AB - We have prepared the first MRI prodrug-procontrast complex by conjugating doxorubicin to a Gd(III) chelate using an acid-labile linker. The relaxometric properties of the adduct and pH activation are reported.

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JO - Inorganic Chemistry

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SN - 0020-1669

IS - 21

ER -

Synthesis and characterization of a doxorubicin-Gd(III) contrast agent conjugate: A new approach toward prodrug-procontrast complexes

Abstract

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