Synthesis and characterization of multifunctional chitosan-Mnfe2o4 nanoparticles for magnetic hyperthermia and drug delivery

Dong Hyun Kim, David E. Nikles, Christopher S. Brazel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

Multifunctional nanoparticles composed of MnFe2O4 were encapsulated in chitosan for investigation of system to combine magnetically-triggered drug delivery and localized hyperthermia for cancer treatment with the previously published capacity of MnFe2O4 to be used as an efficient MRI contrast agent for cancer diagnosis. This paper focuses on the synthesis and characterization of magnetic MnFe2O4 nanoparticles, their dispersion in water and their incorporation in chitosan, which serves as a drug carrier. The surface of the MnFe2O4 nanoparticles was modified with meso-2,3-di-mercaptosuccinic acid (DMSA) to develop stable aqueous dispersions. The nanoparticles were coated with chitosan, and the magnetic properties, heat generation and hydrodynamic size of chitosancoated MnFe2O4 were evaluated for various linker concentrations and in a range of pH conditions.

Original languageEnglish (US)
Pages (from-to)4051-4065
Number of pages15
JournalMaterials
Volume3
Issue number7
DOIs
StatePublished - Dec 1 2010

Keywords

  • Chitosan
  • Drug delivery
  • Magnetic hyperthermia
  • Mnfeo nanoparticles
  • Multifunctional magnetic nanoparticles

ASJC Scopus subject areas

  • Materials Science(all)

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