Synthesis and characterization of ruthenium and rhenium nucleosides

Peijiao Wang, Jeremiah E. Miller, Lawrence M. Henling, Charlotte L. Stern, Natia L. Frank, Amanda L. Eckermann, Thomas J. Meade*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We report the synthesis and characterization of new ruthenium and rhenium nucleosides [Ru(tolyl-acac)2(IMPy)-T] (tolyl-acac = di(p-methylbenzonatemethane), IMPy = 2′-iminomethylpyridine, T = thymidine) (5) and [Re(CO)3-(IMPy)-T]Cl (9), respectively. Structural analysis of 9 shows that the incorporation of this metal complex causes minimal perturbation to the sugar backbone and the nucleobase. Eletrochemical (5, E1/2 = 0.265 V vs NHE; 9, E1/2 = 1.67 V vs NHE), absorption (5, λmax = 600, 486 nm; 9, λmax = 388 nm), and emission (9, λmax = 770 nm, π = 17 ns) data indicate that 5 and 9 are suitable probes for DNA-mediated ground-state electron-transfer studies. The separation and characterization of diastereoisomers of 5 and bipyridyl-based ruthenium nucleoside [Ru(bpy) 2-(IMPy)-T]2+ (7) are reported.

Original languageEnglish (US)
Pages (from-to)9853-9862
Number of pages10
JournalInorganic chemistry
Volume46
Issue number23
DOIs
StatePublished - Nov 12 2007

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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