A general method for the hydroxylation of the 18-methyl group in gibberellins has been developed, as demonstrated by the successful synthesis of 18-hydroxy GA4 (GA131) by means of a tandem process involving the conjugate addition of alkoxides to the α-methylene lactone moiety of a ring A-seco-gibberellin followed by an intramolecular aldol reaction.
|Original language||English (US)|
|Number of pages||13|
|Journal||Organic and Biomolecular Chemistry|
|State||Published - Jul 3 2006|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry