Synthesis and confirmation of structure for the gibberellin GA 131 (18-hydroxy-GA4)

James R. Crow, Regan J. Thomson, Lewis N. Mander*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A general method for the hydroxylation of the 18-methyl group in gibberellins has been developed, as demonstrated by the successful synthesis of 18-hydroxy GA4 (GA131) by means of a tandem process involving the conjugate addition of alkoxides to the α-methylene lactone moiety of a ring A-seco-gibberellin followed by an intramolecular aldol reaction.

Original languageEnglish (US)
Pages (from-to)2532-2544
Number of pages13
JournalOrganic and Biomolecular Chemistry
Issue number13
StatePublished - Jul 3 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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