Abstract
A general method for the hydroxylation of the 18-methyl group in gibberellins has been developed, as demonstrated by the successful synthesis of 18-hydroxy GA4 (GA131) by means of a tandem process involving the conjugate addition of alkoxides to the α-methylene lactone moiety of a ring A-seco-gibberellin followed by an intramolecular aldol reaction.
Original language | English (US) |
---|---|
Pages (from-to) | 2532-2544 |
Number of pages | 13 |
Journal | Organic and Biomolecular Chemistry |
Volume | 4 |
Issue number | 13 |
DOIs | |
State | Published - Jul 3 2006 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry