Synthesis and Evaluation of GdIII-Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate-Specific Membrane Antigen

Sangeeta Ray Banerjee, Ethel J. Ngen, Matthew W. Rotz, Samata Kakkad, Ala Lisok, Richard Pracitto, Mrudula Pullambhatla, Zhengping Chen, Tariq Shah, Dmitri Artemov, Thomas J. Meade, Zaver M. Bhujwalla, Martin G. Pomper

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Magnetic resonance (MR) imaging is advantageous because it concurrently provides anatomic, functional, and molecular information. MR molecular imaging can combine the high spatial resolution of this established clinical modality with molecular profiling in vivo. However, as a result of the intrinsically low sensitivity of MR imaging, high local concentrations of biological targets are required to generate discernable MR contrast. We hypothesize that the prostate-specific membrane antigen (PSMA), an attractive target for imaging and therapy of prostate cancer, could serve as a suitable biomarker for MR-based molecular imaging. We have synthesized three new high-affinity, low-molecular-weight GdIII-based PSMA-targeted contrast agents containing one to three GdIII chelates per molecule. We evaluated the relaxometric properties of these agents in solution, in prostate cancer cells, and in an in vivo experimental model to demonstrate the feasibility of PSMA-based MR molecular imaging.

Original languageEnglish (US)
Pages (from-to)10778-10782
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number37
DOIs
StatePublished - Sep 1 2015

Keywords

  • cancer
  • gadolinium
  • imaging agents
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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