Synthesis and Structure-Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia

Michelle A. Estrada, Xiao Zhao, Kristin Lorent, Alyssa Kriegermeier, Seika A. Nagao, Simon Berritt, Rebecca G. Wells*, Michael Pack, Jeffrey D. Winkler

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations


We report the first synthesis of the plant isoflavonoid biliatresone. The convergent synthesis has been applied to the synthesis of several analogs, which have facilitated the first structure-activity relationship study for this environmental toxin that, on ingestion, recapitulates the phenotype of biliary atresia.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalACS Medicinal Chemistry Letters
Issue number1
StatePublished - Jan 11 2018



  • Biliary atresia
  • biliatresone
  • isoflavonoid
  • structure-activity relationships

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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