@article{189246c4b0224365a25d2059cb46dfde,
title = "Synthesis and Structure-Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia",
abstract = "We report the first synthesis of the plant isoflavonoid biliatresone. The convergent synthesis has been applied to the synthesis of several analogs, which have facilitated the first structure-activity relationship study for this environmental toxin that, on ingestion, recapitulates the phenotype of biliary atresia.",
keywords = "Biliary atresia, biliatresone, isoflavonoid, structure-activity relationships",
author = "Estrada, {Michelle A.} and Xiao Zhao and Kristin Lorent and Alyssa Kriegermeier and Nagao, {Seika A.} and Simon Berritt and Wells, {Rebecca G.} and Michael Pack and Winkler, {Jeffrey D.}",
note = "Funding Information: The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript. Funding Generous financial support of the Fred and Suzanne Biesecker Pediatric Liver Center is gratefully acknowledged. We would also like to thank the National Institutes of Health (NIH S10 OD011980) for support of the Penn High Throughput Screening Center, NIH R01 DK092111 (to R.G.W. and M.P.), the University of Pennsylvania for a Postdoctoral Fellowship for Academic Diversity (to M.A.E.), and the CTSA KL2Mentored Career Development Award (1KL2TR001879-01 to X.Z.). Notes The authors declare no competing financial interest. Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2018",
month = jan,
day = "11",
doi = "10.1021/acsmedchemlett.7b00479",
language = "English (US)",
volume = "9",
pages = "61--64",
journal = "ACS Medicinal Chemistry Letters",
issn = "1948-5875",
publisher = "American Chemical Society",
number = "1",
}