We report the first synthesis of the plant isoflavonoid biliatresone. The convergent synthesis has been applied to the synthesis of several analogs, which have facilitated the first structure-activity relationship study for this environmental toxin that, on ingestion, recapitulates the phenotype of biliary atresia.
- Biliary atresia
- structure-activity relationships
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry