Synthesis and Structure-Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia

Michelle A. Estrada, Xiao Zhao, Kristin Lorent, Alyssa Kriegermeier, Seika A. Nagao, Simon Berritt, Rebecca G. Wells*, Michael Pack, Jeffrey D. Winkler

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We report the first synthesis of the plant isoflavonoid biliatresone. The convergent synthesis has been applied to the synthesis of several analogs, which have facilitated the first structure-activity relationship study for this environmental toxin that, on ingestion, recapitulates the phenotype of biliary atresia.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalACS Medicinal Chemistry Letters
Volume9
Issue number1
DOIs
StatePublished - Jan 11 2018

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Keywords

  • Biliary atresia
  • biliatresone
  • isoflavonoid
  • structure-activity relationships

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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