Synthesis in living cells with the assistance of supramolecular nanocarriers

Sherif Shaban Ragab, Ek Raj Thapaliya, Yang Zhang, Sicheng Tang, Jeffrey Blye McMahan, Sheyum Syed, Burjor Captain, Françisco M. Raymo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Independent supramolecular nanocarriers can transport pairs of complementary reactants inside living cells in two consecutive incubation steps. After the second internalization step, the nonemissive reactants produce a fluorescent product with the concomitant appearance of intense fluorescence exclusively in the intracellular space. These results demonstrate that supramolecular delivery can be exploited to perform chemical reactions inside target cells and can lead to valuable strategies for the intracellular synthesis of drugs.

Original languageEnglish (US)
Pages (from-to)32441-32445
Number of pages5
JournalRSC Advances
Issue number39
StatePublished - 2016

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)


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