Synthesis in living cells with the assistance of supramolecular nanocarriers

Sherif Shaban Ragab; Ek Raj Thapaliya; Yang Zhang; Sicheng Tang; Jeffrey Blye McMahan; Sheyum Syed; Burjor Captain; Françisco M. Raymo

doi:10.1039/c6ra04335f

Synthesis in living cells with the assistance of supramolecular nanocarriers

Sherif Shaban Ragab, Ek Raj Thapaliya, Yang Zhang, Sicheng Tang, Jeffrey Blye McMahan, Sheyum Syed, Burjor Captain, Françisco M. Raymo^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Independent supramolecular nanocarriers can transport pairs of complementary reactants inside living cells in two consecutive incubation steps. After the second internalization step, the nonemissive reactants produce a fluorescent product with the concomitant appearance of intense fluorescence exclusively in the intracellular space. These results demonstrate that supramolecular delivery can be exploited to perform chemical reactions inside target cells and can lead to valuable strategies for the intracellular synthesis of drugs.

Original language	English (US)
Pages (from-to)	32441-32445
Number of pages	5
Journal	RSC Advances
Volume	6
Issue number	39
DOIs	https://doi.org/10.1039/c6ra04335f
State	Published - 2016

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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abstract = "Independent supramolecular nanocarriers can transport pairs of complementary reactants inside living cells in two consecutive incubation steps. After the second internalization step, the nonemissive reactants produce a fluorescent product with the concomitant appearance of intense fluorescence exclusively in the intracellular space. These results demonstrate that supramolecular delivery can be exploited to perform chemical reactions inside target cells and can lead to valuable strategies for the intracellular synthesis of drugs.",

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AU - Ragab, Sherif Shaban

AU - Thapaliya, Ek Raj

AU - Zhang, Yang

AU - Tang, Sicheng

AU - McMahan, Jeffrey Blye

AU - Syed, Sheyum

AU - Captain, Burjor

AU - Raymo, Françisco M.

PY - 2016

Y1 - 2016

N2 - Independent supramolecular nanocarriers can transport pairs of complementary reactants inside living cells in two consecutive incubation steps. After the second internalization step, the nonemissive reactants produce a fluorescent product with the concomitant appearance of intense fluorescence exclusively in the intracellular space. These results demonstrate that supramolecular delivery can be exploited to perform chemical reactions inside target cells and can lead to valuable strategies for the intracellular synthesis of drugs.

AB - Independent supramolecular nanocarriers can transport pairs of complementary reactants inside living cells in two consecutive incubation steps. After the second internalization step, the nonemissive reactants produce a fluorescent product with the concomitant appearance of intense fluorescence exclusively in the intracellular space. These results demonstrate that supramolecular delivery can be exploited to perform chemical reactions inside target cells and can lead to valuable strategies for the intracellular synthesis of drugs.

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ER -

Synthesis in living cells with the assistance of supramolecular nanocarriers

Abstract

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