TY - JOUR
T1 - Synthesis of 1-amino-1H-indole-3-carboxylates by copper(I)-catalyzed intramolecular amination of aryl bromides
AU - Melkonyan, Ferdinand
AU - Topolyan, Artyom
AU - Yurovskaya, Marina
AU - Karchava, Alexander
PY - 2008/12
Y1 - 2008/12
N2 - A simple route to various N-substituted 1-amino-1H-indole-3-carboxylates by use of copper(I)-catalyzed intramolecular N-arylation has been established. For the preparation of N-monosubstituted and N-unsubstituted derivatives, the cyclization of Boc-protected enehydrazines and subsequent deprotection were applied. Furthermore, 1-alkoxyindole-3-carboxylates can be synthesized by use of the same protocol
AB - A simple route to various N-substituted 1-amino-1H-indole-3-carboxylates by use of copper(I)-catalyzed intramolecular N-arylation has been established. For the preparation of N-monosubstituted and N-unsubstituted derivatives, the cyclization of Boc-protected enehydrazines and subsequent deprotection were applied. Furthermore, 1-alkoxyindole-3-carboxylates can be synthesized by use of the same protocol
KW - Annulation
KW - C-N coupling
KW - Copper
KW - Indoles
KW - Nitrogen heterocycles
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U2 - 10.1002/ejoc.200800777
DO - 10.1002/ejoc.200800777
M3 - Article
AN - SCOPUS:56749134435
SN - 1434-193X
SP - 5952
EP - 5956
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
IS - 35
ER -