Synthesis of 1-indole substituted β-carboline alkaloid and its derivatives and evaluation of their preliminary antitumor activities

Xiao Chun Dong, Ren Wen*, Jian Bin Zheng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Aim: To synthesize eudistomin U and its 6-OCH3/Br derivatives and 5′-Br derivatives as antitumor agents. Methods: Using tryptamine and indole-3-aldehyde as starting materials, through condensation, Pictet-Spengler cyclization and dehydrogenation three steps, the alkaloids and its derivatives were prepared. Results: The structures of the compounds were determined by 1HNMR, MS and HRMS. Antitumor activity in vitro was tested. Conclusion: Eudistomin U and its derivatives were synthesized. The results showed that they all showed antitumor activities against mouse P388 strain.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalYaoxue Xuebao
Volume39
Issue number4
StatePublished - Apr 1 2004

Keywords

  • Antitumor
  • Derivatives
  • Eudistomin U
  • Synthesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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