Aim: To synthesize eudistomin U and its 6-OCH3/Br derivatives and 5′-Br derivatives as antitumor agents. Methods: Using tryptamine and indole-3-aldehyde as starting materials, through condensation, Pictet-Spengler cyclization and dehydrogenation three steps, the alkaloids and its derivatives were prepared. Results: The structures of the compounds were determined by 1HNMR, MS and HRMS. Antitumor activity in vitro was tested. Conclusion: Eudistomin U and its derivatives were synthesized. The results showed that they all showed antitumor activities against mouse P388 strain.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Apr 1 2004|
- Eudistomin U
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)