Synthesis of 1-indole substituted β-carboline alkaloid and its derivatives and evaluation of their preliminary antitumor activities

Xiao Chun Dong; Ren Wen; Jian Bin Zheng

Synthesis of 1-indole substituted β-carboline alkaloid and its derivatives and evaluation of their preliminary antitumor activities

Xiao Chun Dong, Ren Wen^*, Jian Bin Zheng

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Aim: To synthesize eudistomin U and its 6-OCH₃/Br derivatives and 5′-Br derivatives as antitumor agents. Methods: Using tryptamine and indole-3-aldehyde as starting materials, through condensation, Pictet-Spengler cyclization and dehydrogenation three steps, the alkaloids and its derivatives were prepared. Results: The structures of the compounds were determined by ¹HNMR, MS and HRMS. Antitumor activity in vitro was tested. Conclusion: Eudistomin U and its derivatives were synthesized. The results showed that they all showed antitumor activities against mouse P388 strain.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	Yaoxue Xuebao
Volume	39
Issue number	4
State	Published - Apr 1 2004

Keywords

Antitumor
Derivatives
Eudistomin U
Synthesis

ASJC Scopus subject areas

Molecular Medicine
Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{9adc7bb811cc4c1aa1420a67cbadb378,

title = "Synthesis of 1-indole substituted β-carboline alkaloid and its derivatives and evaluation of their preliminary antitumor activities",

abstract = "Aim: To synthesize eudistomin U and its 6-OCH3/Br derivatives and 5′-Br derivatives as antitumor agents. Methods: Using tryptamine and indole-3-aldehyde as starting materials, through condensation, Pictet-Spengler cyclization and dehydrogenation three steps, the alkaloids and its derivatives were prepared. Results: The structures of the compounds were determined by 1HNMR, MS and HRMS. Antitumor activity in vitro was tested. Conclusion: Eudistomin U and its derivatives were synthesized. The results showed that they all showed antitumor activities against mouse P388 strain.",

keywords = "Antitumor, Derivatives, Eudistomin U, Synthesis",

author = "Dong, {Xiao Chun} and Ren Wen and Zheng, {Jian Bin}",

year = "2004",

month = apr,

day = "1",

language = "English (US)",

volume = "39",

pages = "259--262",

journal = "Yaoxue Xuebao",

issn = "0513-4870",

publisher = "Zhonghua Yixuehui Zazhishe",

number = "4",

}

TY - JOUR

T1 - Synthesis of 1-indole substituted β-carboline alkaloid and its derivatives and evaluation of their preliminary antitumor activities

AU - Dong, Xiao Chun

AU - Wen, Ren

AU - Zheng, Jian Bin

PY - 2004/4/1

Y1 - 2004/4/1

N2 - Aim: To synthesize eudistomin U and its 6-OCH3/Br derivatives and 5′-Br derivatives as antitumor agents. Methods: Using tryptamine and indole-3-aldehyde as starting materials, through condensation, Pictet-Spengler cyclization and dehydrogenation three steps, the alkaloids and its derivatives were prepared. Results: The structures of the compounds were determined by 1HNMR, MS and HRMS. Antitumor activity in vitro was tested. Conclusion: Eudistomin U and its derivatives were synthesized. The results showed that they all showed antitumor activities against mouse P388 strain.

AB - Aim: To synthesize eudistomin U and its 6-OCH3/Br derivatives and 5′-Br derivatives as antitumor agents. Methods: Using tryptamine and indole-3-aldehyde as starting materials, through condensation, Pictet-Spengler cyclization and dehydrogenation three steps, the alkaloids and its derivatives were prepared. Results: The structures of the compounds were determined by 1HNMR, MS and HRMS. Antitumor activity in vitro was tested. Conclusion: Eudistomin U and its derivatives were synthesized. The results showed that they all showed antitumor activities against mouse P388 strain.

KW - Antitumor

KW - Derivatives

KW - Eudistomin U

KW - Synthesis

UR - http://www.scopus.com/inward/record.url?scp=4444342830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444342830&partnerID=8YFLogxK

M3 - Article

C2 - 15303653

AN - SCOPUS:4444342830

SN - 0513-4870

VL - 39

SP - 259

EP - 262

JO - Yaoxue Xuebao

JF - Yaoxue Xuebao

IS - 4

ER -

Synthesis of 1-indole substituted β-carboline alkaloid and its derivatives and evaluation of their preliminary antitumor activities

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this