Synthesis of 1,2,3-triazoles by cycloadditions of azides with enol ethers

Dario R. Roque; Justin L. Neill; James W. Antoon; Erland P. Stevens

doi:10.1055/s-2005-872116

Synthesis of 1,2,3-triazoles by cycloadditions of azides with enol ethers

Dario R. Roque, Justin L. Neill, James W. Antoon, Erland P. Stevens^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

1,2,3-Triazoles were prepared in good to modest yields by cycloaddition of alkyl azides onto enol ethers under solventless conditions. The reaction can access ring-fused triazoles that are unavailable by azide-alkyne cycloadditions and is easily scalable. The 1,2,3-triazole products bear functionality that may be readily derivatized.

Original language	English (US)
Article number	M10204SS
Pages (from-to)	2497-2502
Number of pages	6
Journal	Synthesis
Issue number	15
DOIs	https://doi.org/10.1055/s-2005-872116
State	Published - Oct 4 2005
Externally published	Yes

Keywords

Azides
Cycloadditions
Heterocycles
Nitrogen
Regioselectivity

ASJC Scopus subject areas

Catalysis
Organic Chemistry

Access to Document

10.1055/s-2005-872116

Cite this

@article{ac93a10a5de44d138dc3ed598a0d85f6,

title = "Synthesis of 1,2,3-triazoles by cycloadditions of azides with enol ethers",

abstract = "1,2,3-Triazoles were prepared in good to modest yields by cycloaddition of alkyl azides onto enol ethers under solventless conditions. The reaction can access ring-fused triazoles that are unavailable by azide-alkyne cycloadditions and is easily scalable. The 1,2,3-triazole products bear functionality that may be readily derivatized.",

keywords = "Azides, Cycloadditions, Heterocycles, Nitrogen, Regioselectivity",

author = "Roque, {Dario R.} and Neill, {Justin L.} and Antoon, {James W.} and Stevens, {Erland P.}",

year = "2005",

month = oct,

day = "4",

doi = "10.1055/s-2005-872116",

language = "English (US)",

pages = "2497--2502",

journal = "Synthesis",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

number = "15",

}

TY - JOUR

T1 - Synthesis of 1,2,3-triazoles by cycloadditions of azides with enol ethers

AU - Roque, Dario R.

AU - Neill, Justin L.

AU - Antoon, James W.

AU - Stevens, Erland P.

PY - 2005/10/4

Y1 - 2005/10/4

N2 - 1,2,3-Triazoles were prepared in good to modest yields by cycloaddition of alkyl azides onto enol ethers under solventless conditions. The reaction can access ring-fused triazoles that are unavailable by azide-alkyne cycloadditions and is easily scalable. The 1,2,3-triazole products bear functionality that may be readily derivatized.

AB - 1,2,3-Triazoles were prepared in good to modest yields by cycloaddition of alkyl azides onto enol ethers under solventless conditions. The reaction can access ring-fused triazoles that are unavailable by azide-alkyne cycloadditions and is easily scalable. The 1,2,3-triazole products bear functionality that may be readily derivatized.

KW - Azides

KW - Cycloadditions

KW - Heterocycles

KW - Nitrogen

KW - Regioselectivity

UR - http://www.scopus.com/inward/record.url?scp=26844458280&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26844458280&partnerID=8YFLogxK

U2 - 10.1055/s-2005-872116

DO - 10.1055/s-2005-872116

M3 - Article

AN - SCOPUS:26844458280

SN - 0039-7881

SP - 2497

EP - 2502

JO - Synthesis

JF - Synthesis

IS - 15

M1 - M10204SS

ER -

Synthesis of 1,2,3-triazoles by cycloadditions of azides with enol ethers

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this