Synthesis of 1,2,3-triazoles by cycloadditions of azides with enol ethers

Dario R. Roque; Justin L. Neill; James W. Antoon; Erland P. Stevens

doi:10.1055/s-2005-872116

Synthesis of 1,2,3-triazoles by cycloadditions of azides with enol ethers

Dario R. Roque, Justin L. Neill, James W. Antoon, Erland P. Stevens^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

1,2,3-Triazoles were prepared in good to modest yields by cycloaddition of alkyl azides onto enol ethers under solventless conditions. The reaction can access ring-fused triazoles that are unavailable by azide-alkyne cycloadditions and is easily scalable. The 1,2,3-triazole products bear functionality that may be readily derivatized.

Original language	English (US)
Article number	M10204SS
Pages (from-to)	2497-2502
Number of pages	6
Journal	Synthesis
Issue number	15
DOIs	https://doi.org/10.1055/s-2005-872116
State	Published - Oct 4 2005
Externally published	Yes

Keywords

Azides
Cycloadditions
Heterocycles
Nitrogen
Regioselectivity

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1055/s-2005-872116

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abstract = "1,2,3-Triazoles were prepared in good to modest yields by cycloaddition of alkyl azides onto enol ethers under solventless conditions. The reaction can access ring-fused triazoles that are unavailable by azide-alkyne cycloadditions and is easily scalable. The 1,2,3-triazole products bear functionality that may be readily derivatized.",

keywords = "Azides, Cycloadditions, Heterocycles, Nitrogen, Regioselectivity",

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doi = "10.1055/s-2005-872116",

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AU - Roque, Dario R.

AU - Neill, Justin L.

AU - Antoon, James W.

AU - Stevens, Erland P.

PY - 2005/10/4

Y1 - 2005/10/4

N2 - 1,2,3-Triazoles were prepared in good to modest yields by cycloaddition of alkyl azides onto enol ethers under solventless conditions. The reaction can access ring-fused triazoles that are unavailable by azide-alkyne cycloadditions and is easily scalable. The 1,2,3-triazole products bear functionality that may be readily derivatized.

AB - 1,2,3-Triazoles were prepared in good to modest yields by cycloaddition of alkyl azides onto enol ethers under solventless conditions. The reaction can access ring-fused triazoles that are unavailable by azide-alkyne cycloadditions and is easily scalable. The 1,2,3-triazole products bear functionality that may be readily derivatized.

KW - Azides

KW - Cycloadditions

KW - Heterocycles

KW - Nitrogen

KW - Regioselectivity

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ER -

Synthesis of 1,2,3-triazoles by cycloadditions of azides with enol ethers

Abstract

Keywords

ASJC Scopus subject areas

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