Synthesis of 1,2,3,4-tetrahydroeudistomin U derivatives and preliminary in vitro antitumor evaluation

Jianbin Zheng; Zhiwen Zhang; Lingling Zhao; Xianyi Sha; Xiaochun Dong; Ren Wen

doi:10.1080/13880200701741120

Synthesis of 1,2,3,4-tetrahydroeudistomin U derivatives and preliminary in vitro antitumor evaluation

Jianbin Zheng, Zhiwen Zhang, Lingling Zhao, Xianyi Sha, Xiaochun Dong, Ren Wen^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A series of novel 2-substituted 1,2,3,4-tetrahydroeudistomin U derivatives were synthesized by the key Pictet-Spengler cyclization reaction and their in vitro antitumor activities were evaluated using Pyricularia oryzae Cavara and Caco-2 cancer cells. Most of the 2-alkyl-1,2,3,4-tetrahydroeudistomin U compounds (19- 23) showed potent inhibitory activities in both of the biological tests. Preliminary structure-activity relationships are also presented.

Original language	English (US)
Pages (from-to)	273-278
Number of pages	6
Journal	Pharmaceutical Biology
Volume	46
Issue number	4
DOIs	https://doi.org/10.1080/13880200701741120
State	Published - Apr 2008

Keywords

1-(indol-3-yl)-1,2,3,4-tetrahydro-β- carboline
Antitumor
Caco-2 cancer cell
Pyricularia oryzae

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/13880200701741120

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title = "Synthesis of 1,2,3,4-tetrahydroeudistomin U derivatives and preliminary in vitro antitumor evaluation",

abstract = "A series of novel 2-substituted 1,2,3,4-tetrahydroeudistomin U derivatives were synthesized by the key Pictet-Spengler cyclization reaction and their in vitro antitumor activities were evaluated using Pyricularia oryzae Cavara and Caco-2 cancer cells. Most of the 2-alkyl-1,2,3,4-tetrahydroeudistomin U compounds (19- 23) showed potent inhibitory activities in both of the biological tests. Preliminary structure-activity relationships are also presented.",

keywords = "1-(indol-3-yl)-1,2,3,4-tetrahydro-β- carboline, Antitumor, Caco-2 cancer cell, Pyricularia oryzae",

author = "Jianbin Zheng and Zhiwen Zhang and Lingling Zhao and Xianyi Sha and Xiaochun Dong and Ren Wen",

year = "2008",

month = apr,

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language = "English (US)",

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pages = "273--278",

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T1 - Synthesis of 1,2,3,4-tetrahydroeudistomin U derivatives and preliminary in vitro antitumor evaluation

AU - Zheng, Jianbin

AU - Zhang, Zhiwen

AU - Zhao, Lingling

AU - Sha, Xianyi

AU - Dong, Xiaochun

AU - Wen, Ren

PY - 2008/4

Y1 - 2008/4

N2 - A series of novel 2-substituted 1,2,3,4-tetrahydroeudistomin U derivatives were synthesized by the key Pictet-Spengler cyclization reaction and their in vitro antitumor activities were evaluated using Pyricularia oryzae Cavara and Caco-2 cancer cells. Most of the 2-alkyl-1,2,3,4-tetrahydroeudistomin U compounds (19- 23) showed potent inhibitory activities in both of the biological tests. Preliminary structure-activity relationships are also presented.

AB - A series of novel 2-substituted 1,2,3,4-tetrahydroeudistomin U derivatives were synthesized by the key Pictet-Spengler cyclization reaction and their in vitro antitumor activities were evaluated using Pyricularia oryzae Cavara and Caco-2 cancer cells. Most of the 2-alkyl-1,2,3,4-tetrahydroeudistomin U compounds (19- 23) showed potent inhibitory activities in both of the biological tests. Preliminary structure-activity relationships are also presented.

KW - 1-(indol-3-yl)-1,2,3,4-tetrahydro-β- carboline

KW - Antitumor

KW - Caco-2 cancer cell

KW - Pyricularia oryzae

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DO - 10.1080/13880200701741120

M3 - Article

AN - SCOPUS:41349105523

SN - 1388-0209

VL - 46

SP - 273

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JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

IS - 4

ER -

Synthesis of 1,2,3,4-tetrahydroeudistomin U derivatives and preliminary in vitro antitumor evaluation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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