Abstract
A series of novel 2-substituted 1,2,3,4-tetrahydroeudistomin U derivatives were synthesized by the key Pictet-Spengler cyclization reaction and their in vitro antitumor activities were evaluated using Pyricularia oryzae Cavara and Caco-2 cancer cells. Most of the 2-alkyl-1,2,3,4-tetrahydroeudistomin U compounds (19- 23) showed potent inhibitory activities in both of the biological tests. Preliminary structure-activity relationships are also presented.
Original language | English (US) |
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Pages (from-to) | 273-278 |
Number of pages | 6 |
Journal | Pharmaceutical Biology |
Volume | 46 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2008 |
Keywords
- 1-(indol-3-yl)-1,2,3,4-tetrahydro-β- carboline
- Antitumor
- Caco-2 cancer cell
- Pyricularia oryzae
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine