Synthesis of 1,2,3,4-tetrahydroeudistomin U derivatives and preliminary in vitro antitumor evaluation

Jianbin Zheng, Zhiwen Zhang, Lingling Zhao, Xianyi Sha, Xiaochun Dong, Ren Wen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

A series of novel 2-substituted 1,2,3,4-tetrahydroeudistomin U derivatives were synthesized by the key Pictet-Spengler cyclization reaction and their in vitro antitumor activities were evaluated using Pyricularia oryzae Cavara and Caco-2 cancer cells. Most of the 2-alkyl-1,2,3,4-tetrahydroeudistomin U compounds (19- 23) showed potent inhibitory activities in both of the biological tests. Preliminary structure-activity relationships are also presented.

Original languageEnglish (US)
Pages (from-to)273-278
Number of pages6
JournalPharmaceutical Biology
Volume46
Issue number4
DOIs
StatePublished - Apr 2008

Keywords

  • 1-(indol-3-yl)-1,2,3,4-tetrahydro-β- carboline
  • Antitumor
  • Caco-2 cancer cell
  • Pyricularia oryzae

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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