Synthesis of a high-purity chemical library reveals a potent inducer of oxidative stress

Jiayue Cui, Kenji Matsumoto, Cindy Y. Wang, Marcus E. Peter, Sergey A. Kozmin

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

(Chemical Equation Presented) Needle in a haystack: Synthesis of a high-purity, biogenic, heterocyclic, 936-member library enabled the identification of a small molecule, triazatricyclamide (1), that potently inhibited the proliferation of several cancer cell lines and induced rapid oxidative stress. Unusually, this agent caused cell death by activating both caspase-dependent and -independent pathways.

Original languageEnglish (US)
Pages (from-to)1224-1227
Number of pages4
JournalChemBioChem
Volume11
Issue number9
DOIs
StatePublished - Jun 14 2010

Keywords

  • Apoptosis
  • Caspases
  • Chemical libraries
  • Cytotoxicity
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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