Synthesis of a high-purity chemical library reveals a potent inducer of oxidative stress

Jiayue Cui; Kenji Matsumoto; Cindy Y. Wang; Marcus E. Peter; Sergey A. Kozmin

doi:10.1002/cbic.201000193

Synthesis of a high-purity chemical library reveals a potent inducer of oxidative stress

Jiayue Cui, Kenji Matsumoto, Cindy Y. Wang, Marcus E. Peter, Sergey A. Kozmin

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

(Chemical Equation Presented) Needle in a haystack: Synthesis of a high-purity, biogenic, heterocyclic, 936-member library enabled the identification of a small molecule, triazatricyclamide (1), that potently inhibited the proliferation of several cancer cell lines and induced rapid oxidative stress. Unusually, this agent caused cell death by activating both caspase-dependent and -independent pathways.

Original language	English (US)
Pages (from-to)	1224-1227
Number of pages	4
Journal	ChemBioChem
Volume	11
Issue number	9
DOIs	https://doi.org/10.1002/cbic.201000193
State	Published - Jun 14 2010

Keywords

Apoptosis
Caspases
Chemical libraries
Cytotoxicity
Reactive oxygen species

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

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AU - Kozmin, Sergey A.

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