Synthesis of a homotrifunctional conjugation reagent based on maleimide chemistry

Omar K. Farha, Richard L. Julius, M. Frederick Hawthorne*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A novel homotrifunctional conjugation reagent, 1,3,5-tris-(N- maleimidomethyl)benzene has been synthesized in high yield with minimum purification. The reactivity of this compound was examined by using l-cysteine as a nucleophile.

Original languageEnglish (US)
Pages (from-to)2619-2622
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number15
DOIs
StatePublished - Apr 10 2006

Keywords

  • 1,3,5-Tris(hydroxymethyl)benzene
  • 1,3,5-Tris-(N- maleimidomethyl)benzene
  • Cysteine
  • Diels-Alder
  • Homotrifunctional conjugation reagent
  • Maleimide
  • Mitsunobu
  • Thiol

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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