@article{900d1777a52f4dbd8b4a50fa07110ab6,
title = "Synthesis of a novel fused pyrrolodiazepine-based library with anti-cancer activity",
abstract = "Development of drugs for new and persistent diseases will increasingly rely on the expansion of accessible chemical space to allow exploration of novel molecular targets. Here we report the synthesis of a library of novel fused heterobicyclic small molecules based on the 1,4-diazepine and 2,4-pyrrolidinedione scaffolds. Key chemical transformations included a Mannich-type condensation and chemoselective N-acylation reactions. Screening shows anti-cancer activity of several library compounds which suggests translational potential of this novel chemical scaffold.",
keywords = "Cancer, Diazepine, Library, Mannich reaction",
author = "Neha Malik and Iyamu, {Iredia D.} and Scheidt, {Karl A.} and Schiltz, {Gary E.}",
note = "Funding Information: Financial support has been provided by the Dr. Scholl Foundation and by the National Cancer Institute of the National Institutes of Health under Award Number R01CA189074. Part of this work was performed by the Northwestern University Medicinal and Synthetic Chemistry Core (ChemCore) at the Center for Molecular Innovation and Drug Discovery (CMIDD), which is funded by the Chicago Biomedical Consortium with support from The Searle Funds at The Chicago Community Trust and Cancer Center Support Grant P30 CA060553 from the National Cancer Institute awarded to the Robert H. Lurie Comprehensive Cancer Center. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = apr,
day = "11",
doi = "10.1016/j.tetlet.2018.03.021",
language = "English (US)",
volume = "59",
pages = "1513--1516",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "15",
}
