Synthesis of arginine-containing hydroxamate dipeptidomimetics

Jiwon Seo, Richard B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The syntheses of arginine-containing hydroxamates using various peptide coupling methods are described. Fmoc-Arg(NO2)-Cl prepared at low temperature did not undergo intramolecular δ-lactam formation and effectively provided desired hydroxamates (8 and 10) in good yields. Fmoc and N-nitro protecting groups can be easily removed. Therefore, this report provides a facile synthesis of arginine-containing peptidomimetic compounds.

Original languageEnglish (US)
Pages (from-to)4069-4073
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number24
DOIs
StatePublished - Jun 12 2006

Keywords

  • Acid chloride
  • Arginine
  • Hydroxamate
  • Peptidomimetics

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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