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Synthesis of cyclopropane isosteres of the antiepilepsy drug vigabatrin and evaluation of their inhibition of GABA aminotransferase
Zhiyong Wang,
Richard B. Silverman
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Corresponding author for this work
Chemistry
Research output
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Contribution to journal
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Article
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peer-review
9
Scopus citations
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Dive into the research topics of 'Synthesis of cyclopropane isosteres of the antiepilepsy drug vigabatrin and evaluation of their inhibition of GABA aminotransferase'. Together they form a unique fingerprint.
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Keyphrases
Aminobutyric Acid
33%
Aminotransferase
33%
Anti-epilepsy Drugs
100%
Cyclopropanols
33%
Enamines
33%
GABA-AT
66%
GABA-transaminase
100%
Inactivator
33%
Isostere
100%
Mechanism-based Inactivator
33%
Michael Addition
66%
Propylene
100%
Pyridoxal-5′-phosphate-dependent Enzymes
33%
Vigabatrin
100%
Vinyl
33%
Vinyl Group
33%
Pharmacology, Toxicology and Pharmaceutical Science
4 Aminobutyrate Aminotransferase
100%
4 Aminobutyric Acid
75%
Cyclopropane
100%
Enamine
25%
Pyridoxal 5 Phosphate
25%
Vigabatrin
100%
Vinyl Derivative
25%