Synthesis of (-)-epibatidine

David A. Evans*, Karl A. Scheidt, C. Wade Downey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

matrix presented The synthesis of (-)-epibatidine has been accomplished utilizing a highly exo-selective asymmetric hetero Diels-Alder reaction. The key steps employed to transform the resulting bicycle into the natural product include a fluoride-promoted fragmentation and a Hofmann rearrangement.

Original languageEnglish (US)
Pages (from-to)3009-3012
Number of pages4
JournalOrganic Letters
Volume3
Issue number19
DOIs
StatePublished - Sep 20 2001

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of (-)-epibatidine'. Together they form a unique fingerprint.

Cite this