"Chemical equation presented" In an effort to develop effective new optical contrast agents, we report the synthesis of porphyrazines (pzs) of the form H2[pz(A4-n;Cn)], n = 1, and 2 (trans-), where "A" represents peripheral heteroatom (S- and O-) Rgroups and "C" is a fused, β,β′-diisopropyloxynapntho group. The sulfide appended trans-H2[pz(A2;C 2)] pz (7) has the longest wavelength absorption, ∼874 nm (log ε= 4.53), and S1 fluorescence at ∼927 nm, wavelengths within the window of maximum tissue penetration. Emission from the oxygen-atom appended naphtho-pzs (8, 9) has been observed within carcinoma cells, confirming cellular uptake and their potential use as optical agents.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Organic Chemistry|
|State||Published - Mar 5 2010|
ASJC Scopus subject areas
- Organic Chemistry
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CCDC 812181: Experimental Crystal Structure Determination
Trivedi, E. R. (Creator), Lee, S. (Creator), Zong, H. (Creator), Blumenfeld, C. M. (Creator), Barrett, A. G. M. (Creator) & Hoffman, B. M. (Creator), Cambridge Crystallographic Data Centre, 2011
DOI: 10.5517/ccw84dn, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccw84dn&sid=DataCite