Synthesis of iron oxide nanocube patched Janus magnetic nanocarriers for cancer therapeutic applications

Wentao Zhang; Hyunjun Choi; Bo Yu; Dong Hyun Kim

doi:10.1039/d0cc03614e

Synthesis of iron oxide nanocube patched Janus magnetic nanocarriers for cancer therapeutic applications

Wentao Zhang, Hyunjun Choi, Bo Yu, Dong Hyun Kim^*

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Janus magnetic particles, which can be customized for various multifunctionalities, have promising potential for cancer therapeutic carriers. Herein we synthesized iron oxide nanocube (IONC) patched Janus magnetic nanocarriers (IONCs-P-JMNC) using emulsification and interface evaporation/assembly. Novel IONC patches were generated with an optimal ratio of CTAB and oleic acid coated IONCs in the emulsion. 2D assembled IONC patched Janus magnetic porous silica nanocarriers (IONCs-P-JMNC) formed with the addition of tetraethyl orthosilicate (TEOS). The anisotropically IONC patched Janus nanocarriers, allowing effective MRI T2∗ contrast and magneto-mechanical properties, are expected to be used for a new type of multifunctional carrier in cancer therapeutic applications. This journal is

Original language	English (US)
Pages (from-to)	8810-8813
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	62
DOIs	https://doi.org/10.1039/d0cc03614e
State	Published - Aug 11 2020

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Synthesis of iron oxide nanocube patched Janus magnetic nanocarriers for cancer therapeutic applications",

abstract = "Janus magnetic particles, which can be customized for various multifunctionalities, have promising potential for cancer therapeutic carriers. Herein we synthesized iron oxide nanocube (IONC) patched Janus magnetic nanocarriers (IONCs-P-JMNC) using emulsification and interface evaporation/assembly. Novel IONC patches were generated with an optimal ratio of CTAB and oleic acid coated IONCs in the emulsion. 2D assembled IONC patched Janus magnetic porous silica nanocarriers (IONCs-P-JMNC) formed with the addition of tetraethyl orthosilicate (TEOS). The anisotropically IONC patched Janus nanocarriers, allowing effective MRI T2∗ contrast and magneto-mechanical properties, are expected to be used for a new type of multifunctional carrier in cancer therapeutic applications. This journal is ",

author = "Wentao Zhang and Hyunjun Choi and Bo Yu and Kim, {Dong Hyun}",

note = "Funding Information: This work was supported by grants R01CA218659 and R01EB026207 from the National Cancer Institute and National Institute of Biomedical Imaging and Bioengineering. This work was also supported by the Center for Translational Imaging and Mouse Histology and Phenotyping Laboratory at Northwestern University. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2020",

month = aug,

day = "11",

doi = "10.1039/d0cc03614e",

language = "English (US)",

volume = "56",

pages = "8810--8813",

journal = "Chemical Communications",

issn = "1359-7345",

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T1 - Synthesis of iron oxide nanocube patched Janus magnetic nanocarriers for cancer therapeutic applications

AU - Zhang, Wentao

AU - Choi, Hyunjun

AU - Yu, Bo

AU - Kim, Dong Hyun

N1 - Funding Information: This work was supported by grants R01CA218659 and R01EB026207 from the National Cancer Institute and National Institute of Biomedical Imaging and Bioengineering. This work was also supported by the Center for Translational Imaging and Mouse Histology and Phenotyping Laboratory at Northwestern University. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2020/8/11

Y1 - 2020/8/11

N2 - Janus magnetic particles, which can be customized for various multifunctionalities, have promising potential for cancer therapeutic carriers. Herein we synthesized iron oxide nanocube (IONC) patched Janus magnetic nanocarriers (IONCs-P-JMNC) using emulsification and interface evaporation/assembly. Novel IONC patches were generated with an optimal ratio of CTAB and oleic acid coated IONCs in the emulsion. 2D assembled IONC patched Janus magnetic porous silica nanocarriers (IONCs-P-JMNC) formed with the addition of tetraethyl orthosilicate (TEOS). The anisotropically IONC patched Janus nanocarriers, allowing effective MRI T2∗ contrast and magneto-mechanical properties, are expected to be used for a new type of multifunctional carrier in cancer therapeutic applications. This journal is

AB - Janus magnetic particles, which can be customized for various multifunctionalities, have promising potential for cancer therapeutic carriers. Herein we synthesized iron oxide nanocube (IONC) patched Janus magnetic nanocarriers (IONCs-P-JMNC) using emulsification and interface evaporation/assembly. Novel IONC patches were generated with an optimal ratio of CTAB and oleic acid coated IONCs in the emulsion. 2D assembled IONC patched Janus magnetic porous silica nanocarriers (IONCs-P-JMNC) formed with the addition of tetraethyl orthosilicate (TEOS). The anisotropically IONC patched Janus nanocarriers, allowing effective MRI T2∗ contrast and magneto-mechanical properties, are expected to be used for a new type of multifunctional carrier in cancer therapeutic applications. This journal is

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JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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Synthesis of iron oxide nanocube patched Janus magnetic nanocarriers for cancer therapeutic applications

Abstract

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