Abstract
Janus magnetic particles, which can be customized for various multifunctionalities, have promising potential for cancer therapeutic carriers. Herein we synthesized iron oxide nanocube (IONC) patched Janus magnetic nanocarriers (IONCs-P-JMNC) using emulsification and interface evaporation/assembly. Novel IONC patches were generated with an optimal ratio of CTAB and oleic acid coated IONCs in the emulsion. 2D assembled IONC patched Janus magnetic porous silica nanocarriers (IONCs-P-JMNC) formed with the addition of tetraethyl orthosilicate (TEOS). The anisotropically IONC patched Janus nanocarriers, allowing effective MRI T2∗ contrast and magneto-mechanical properties, are expected to be used for a new type of multifunctional carrier in cancer therapeutic applications.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8810-8813 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 56 |
| Issue number | 62 |
| DOIs | |
| State | Published - Aug 11 2020 |
Funding
This work was supported by grants R01CA218659 and R01EB026207 from the National Cancer Institute and National Institute of Biomedical Imaging and Bioengineering. This work was also supported by the Center for Translational Imaging and Mouse Histology and Phenotyping Laboratory at Northwestern University.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Metals and Alloys
- Materials Chemistry
- Surfaces, Coatings and Films
- General Chemistry
- Catalysis
