Synthesis of multimeric MR contrast agents for cellular imaging

Ying Song; Ellen K. Kohlmeir; Thomas J. Meade

doi:10.1021/ja0777990

Synthesis of multimeric MR contrast agents for cellular imaging

Ying Song, Ellen K. Kohlmeir, Thomas J. Meade

Chemistry

Research output: Contribution to journal › Article › peer-review

170 Scopus citations

Abstract

We have prepared a series of molecular multimeric MR contrast agents for cell labeling that are easy to synthesize, relatively low molecular weight, and biocompatible. The relaxivities of the agents range from 17 to 85 mM^-1s^-1. Cellular uptake is concentration dependent and viability is excellent. MR images of cell pellets reveal a marked increase in observed signal intensity.

Original language	English (US)
Pages (from-to)	6662-6663
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	130
Issue number	21
DOIs	https://doi.org/10.1021/ja0777990
State	Published - May 28 2008

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja0777990

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title = "Synthesis of multimeric MR contrast agents for cellular imaging",

abstract = "We have prepared a series of molecular multimeric MR contrast agents for cell labeling that are easy to synthesize, relatively low molecular weight, and biocompatible. The relaxivities of the agents range from 17 to 85 mM-1s-1. Cellular uptake is concentration dependent and viability is excellent. MR images of cell pellets reveal a marked increase in observed signal intensity.",

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AB - We have prepared a series of molecular multimeric MR contrast agents for cell labeling that are easy to synthesize, relatively low molecular weight, and biocompatible. The relaxivities of the agents range from 17 to 85 mM-1s-1. Cellular uptake is concentration dependent and viability is excellent. MR images of cell pellets reveal a marked increase in observed signal intensity.

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Synthesis of multimeric MR contrast agents for cellular imaging

Abstract

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