Synthesis of Nanoparticles

Anthony M. Rush*, Carrie R. James, Nathan C. Gianneschi

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


This chapter provides a survey of the various approaches that have been taken toward the preparation of polymeric nanoparticles from ring-opening metathesis polymerization (ROMP). The assembly of amphiphilic block copolymers to generate discrete nanoscale structures is primarily driven by the hydrophobic effect, with micelle size and shape governed by a set of basic principles rooted in surfactant phase-separation behavior. Along with the hydrophobic effect, micelle formation is further guided by the volume ratio of the hydrophobic and hydrophilic polymer domains. Access to these various phases is possible via a number of synthetic ROMP-based approaches. These approaches are divided into three distinct classes and involve grafting-through, grafting-to, or grafting-from ROMP polymer backbones to achieve the amphiphilicity necessary to guide nanoparticle formation. The grafting-from method involves the use of an orthogonal polymerization technique to either polymerize from a ROMP copolymer backbone or to provide a polymer scaffold capable of initiating ROMP.

Original languageEnglish (US)
Title of host publicationVolume 3
Subtitle of host publicationPolymer Synthesis
Number of pages34
ISBN (Electronic)9783527674107
ISBN (Print)9783527334247
StatePublished - Jan 1 2015


  • Grafting-from approach
  • Grafting-through approach
  • Grafting-to approach
  • Polymeric nanoparticles
  • Ring-opening metathesis polymerization (ROMP)

ASJC Scopus subject areas

  • Chemistry(all)

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