Synthesis of novel cinnamanilides as potential immunosuppressive agents

Lei Shi*, Lu Wang, Zhi Wang, Hai Liang Zhu, Qiao Song

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A series of new cinnamanilides (6-40) were synthesized and their immunosuppressive activity and cytotoxicity were evaluated. Most of the cinnamanilides showed good immunosuppressive activity. Among the synthesized compounds, (Z)-N-(4-bromophenyl)-2-methoxy-3-(4-methoxyphenyl)acrylamide (37) and (Z)-2-methoxy-3-(4-methoxyphenyl)-N-p-tolylacrylamide (38) exhibited potent immunosuppressive activity (IC 50 = 1.77 ± 0.33 and 0.94 ± 0.13 μM) without significant cytotoxicity.

Original languageEnglish (US)
Pages (from-to)585-593
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume47
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • Cinnamanilides
  • Immunosuppressive activity
  • Synthesis

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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