Synthesis of phosphatidylethanol - A potential marker for adult males at risk for alcoholism

G. C. Mueller, M. F. Fleming, M. A. LeMahieu, G. S. Lybrand, K. J. Barry

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Phosphatidylethanol, whose synthesis is catalyzed by a phospholipase D in a transphosphatidylation reaction, is a unique metabolite of ethanol. Phorbol 12-tetradecanoate 13-acetate, a tumor-promoting phorbol ester and stimulator of protein kinase C, activates this enzyme in peripheral blood lymphocytes. This system has been developed into an assay for measuring the potential of this pathway in human subjects. A pilot study of phosphatidylethanol synthesis in lymphocytes of adult males who have both an alcohol dependency and a family history of alcoholism has revealed that the average potential for phosphatidylethanol synthesis in this population is significantly elevated over that of control subjects.

Original languageEnglish (US)
Pages (from-to)9778-9782
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number24
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • General

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