Synthesis of (S)-2-Boc-Amino-8-(R)-(tert-butyldimethylsilanyloxy)decanoic acid, a precursor to the unusual amino acid residue of the anticancer agent microsporin B

Wenxin Gu, Richard B Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

(S)-2-Boc-Amino-8-(R)-(tert-butyldimethylsilanyloxy)decanoic acid, the Boc-protected precursor of an unusual amino acid residue for the synthesis of microsporin B, was synthesized. The key steps include a Suzuki coupling followed by asymmetric homogeneous hydrogenation.

Original languageEnglish (US)
Pages (from-to)5438-5440
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number42
DOIs
StatePublished - Oct 19 2011

Keywords

  • Amino acid
  • Asymmetric homogeneous hydrogenation
  • Cyclic tetrapeptide
  • HDAC
  • Microsporin
  • Olefin metathesis
  • Suzuki coupling

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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