Synthesis of vitamin D in skin after burns

Gordon L. Klein*, Tai C. Chen, Michael F. Holick, Craig B. Langman, Heather Price, Mario M. Celis, David N. Herndon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

Severe burn injury is associated with vitamin D deficiency, low bone turnover, and abnormalities in calcium homoeostasis. Patients do not routinely receive vitamin D supplementation and sun exposure is currently not controlled. By analysis of skin biopsy samples for vitamin D3 precursors after exposure to ultraviolet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in children a mean of 14 months after the burn. Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury.

Original languageEnglish (US)
Pages (from-to)291-292
Number of pages2
JournalLancet
Volume363
Issue number9405
DOIs
StatePublished - Jan 24 2004

ASJC Scopus subject areas

  • Medicine(all)

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