Synthesizing interlocked molecules dynamically

Philip C. Haussmann, J. Fraser Stoddart

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


As the complexity of mechanically interlocked molecular architectures increases, it is important to understand the underlying principles, such as molecular recognition and self-assembly processes, that govern the practice of template-directed synthesis necessary to create these particular compounds. In this review, we explain the importance of dynamic processes in the synthesis of mechanically interlocked compounds. We show how many different dynamic covalent bonds have been used in the synthesis of rotaxanes, catenanes, and other higher-order mechanically interlocked compounds, with the goal of revealing the state of the art in dynamic covalent chemistry.

Original languageEnglish (US)
Pages (from-to)136-154
Number of pages19
JournalChemical Record
Issue number2
StatePublished - Apr 6 2009


  • Catenanes
  • Dynamic covalent chemistry
  • Rotaxanes
  • Self-assembly
  • Templated synthesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Materials Chemistry


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