Synthetic high-density lipoprotein-like nanoparticles for cancer therapy

Linda Foit; Francis J. Giles; Leo I. Gordon; Colby Shad Thaxton

doi:10.1586/14737140.2015.990889

Synthetic high-density lipoprotein-like nanoparticles for cancer therapy

Linda Foit, Francis J. Giles, Leo I. Gordon, Colby Shad Thaxton^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

High-density lipoproteins (HDLs) are a diverse group of natural nanoparticles that are most well known for their role in cholesterol transport. However, HDLs have diverse functions that provide significant opportunities for cancer therapy. Presented is a focused review of the ways that synthetic versions of HDL have been used as targeted therapies for cancer, and as vehicles for the delivery of diverse therapeutic cargo to cancer cells. As such, synthetic HDLs are likely to play a central role in the development of next-generation cancer therapies.

Original language	English (US)
Pages (from-to)	27-34
Number of pages	8
Journal	Expert review of anticancer therapy
Volume	15
Issue number	1
DOIs	https://doi.org/10.1586/14737140.2015.990889
State	Published - Jan 1 2014

Keywords

cancer
cholesterol
drug delivery
high-density lipoprotein
nucleic acids
scavenger receptor

ASJC Scopus subject areas

Pharmacology (medical)
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1586/14737140.2015.990889

Cite this

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title = "Synthetic high-density lipoprotein-like nanoparticles for cancer therapy",

abstract = "High-density lipoproteins (HDLs) are a diverse group of natural nanoparticles that are most well known for their role in cholesterol transport. However, HDLs have diverse functions that provide significant opportunities for cancer therapy. Presented is a focused review of the ways that synthetic versions of HDL have been used as targeted therapies for cancer, and as vehicles for the delivery of diverse therapeutic cargo to cancer cells. As such, synthetic HDLs are likely to play a central role in the development of next-generation cancer therapies.",

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author = "Linda Foit and Giles, {Francis J.} and Gordon, {Leo I.} and Thaxton, {Colby Shad}",

note = "Funding Information: CS Thaxton would like to thank the Howard Hughes Medical Institute for a Physician-Scientist Early Career Award, grant funding from the Department of Defense/Air Force Office of Scientific Research (FA95501310192), and grant funding from the National Institutes of Health/National Cancer Institute (U54CA151880 and R01CA167041). Publisher Copyright: {\textcopyright} 2015 Informa UK Ltd.",

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doi = "10.1586/14737140.2015.990889",

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N1 - Funding Information: CS Thaxton would like to thank the Howard Hughes Medical Institute for a Physician-Scientist Early Career Award, grant funding from the Department of Defense/Air Force Office of Scientific Research (FA95501310192), and grant funding from the National Institutes of Health/National Cancer Institute (U54CA151880 and R01CA167041). Publisher Copyright: © 2015 Informa UK Ltd.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - High-density lipoproteins (HDLs) are a diverse group of natural nanoparticles that are most well known for their role in cholesterol transport. However, HDLs have diverse functions that provide significant opportunities for cancer therapy. Presented is a focused review of the ways that synthetic versions of HDL have been used as targeted therapies for cancer, and as vehicles for the delivery of diverse therapeutic cargo to cancer cells. As such, synthetic HDLs are likely to play a central role in the development of next-generation cancer therapies.

AB - High-density lipoproteins (HDLs) are a diverse group of natural nanoparticles that are most well known for their role in cholesterol transport. However, HDLs have diverse functions that provide significant opportunities for cancer therapy. Presented is a focused review of the ways that synthetic versions of HDL have been used as targeted therapies for cancer, and as vehicles for the delivery of diverse therapeutic cargo to cancer cells. As such, synthetic HDLs are likely to play a central role in the development of next-generation cancer therapies.

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KW - drug delivery

KW - high-density lipoprotein

KW - nucleic acids

KW - scavenger receptor

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Synthetic high-density lipoprotein-like nanoparticles for cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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