Synthetic high-density lipoprotein-like nanoparticles for cancer therapy

Linda Foit, Francis J. Giles, Leo I. Gordon, Colby Shad Thaxton*

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

High-density lipoproteins (HDLs) are a diverse group of natural nanoparticles that are most well known for their role in cholesterol transport. However, HDLs have diverse functions that provide significant opportunities for cancer therapy. Presented is a focused review of the ways that synthetic versions of HDL have been used as targeted therapies for cancer, and as vehicles for the delivery of diverse therapeutic cargo to cancer cells. As such, synthetic HDLs are likely to play a central role in the development of next-generation cancer therapies.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalExpert review of anticancer therapy
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • cancer
  • cholesterol
  • drug delivery
  • high-density lipoprotein
  • nucleic acids
  • scavenger receptor

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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