System model for laser-scanning photoacoustic microscopy

Patrick J. La Rivière, Hao F. Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this work we derive a system model for a laser-scanning, optical-resolution photoacoustic microscopy system.We use the model to derive a simple image reconstruction algorithm and then analyze the depth resolution achievable by this algorithm. There has recently been development of high-frequency photoacoustic microscopy (PAM) systems with the ability to image biological tissue at a microscopic scale. The imaging depths achievable (a few mm) are shallower than in photoacoustic tomography (which has lower spatial resolution), but deeper than conventional optical microscopy. PAM usually employs a focused single-element high-frequency ultrasonic transducer and a spatially overlapped optical illumination. These existing PAMs require mechanical scanning of the ultrasonic-optical assembly, which is relatively slow and also not compatible with other optical microscopic modalities such as confocal microscopy, two-photon microscopy, and optical coherence tomography. Recently one of us (H.Z.) has developed a laser-scanning OR-PAM (LSOR-PAM) to demonstrate the feasibility of employing optical scanning in PAM. In LSOR-PAM, the ultrasonic detector is kept stationary and only the laser light is raster-scanned within the FOV during data acquisition. Further improvements in image quality and the development of image quality metrics will benefit from the system model derived in this work.

Original languageEnglish (US)
Title of host publication2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009
Pages3333-3337
Number of pages5
DOIs
StatePublished - Dec 1 2009
Event2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009 - Orlando, FL, United States
Duration: Oct 25 2009Oct 31 2009

Other

Other2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009
CountryUnited States
CityOrlando, FL
Period10/25/0910/31/09

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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