Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain

D. J. Müller*, C. C. Zai, M. Sicard, E. Remington, R. P. Souza, A. K. Tiwari, R. Hwang, O. Likhodi, S. Shaikh, N. Freeman, T. Arenovich, A. Heinz, H. Y. Meltzer, J. A. Lieberman, J. L. Kennedy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Antipsychotic-induced weight gain has emerged as a serious complication in the treatment of patients with most antipsychotics. We have conducted the first in-depth examination of dopamine receptor genes in antipsychotic-induced weight gain. A total of 206 patients (139 of European descent and 56 African Americans) who underwent treatment for chronic schizophrenia or schizoaffective disorder were evaluated after on average over 6 weeks of treatment. Thirty-six tag single nucleotide polymorphisms (SNPs) and one variable-number tandem repeat, spanning the five dopamine receptor genes (DRD1-DRD5) were analyzed. In the total sample, we found a nominally significant association between the DRD2 rs1079598 marker and weight change using a cutoff of 7% gain (P=0.03). When stratifying the sample according to ethnicity and antipsychotics with highest risk for weight gain, we found significant associations in three DRD2 SNPs: rs6277 (C957T), rs1079598 and rs1800497 (TaqIA). The other genes were primarily negative. We provide evidence that dopamine receptor DRD2 gene variants might be associated with antipsychotic-induced weight gain in chronic schizophrenia patients.

Original languageEnglish (US)
Pages (from-to)156-164
Number of pages9
JournalPharmacogenomics Journal
Volume12
Issue number2
DOIs
StatePublished - Apr 2012

Keywords

  • antipsychotic-induced weight gain
  • dopamine receptor genes
  • haplotypes
  • pharmacogenetics
  • polymorphisms
  • schizophrenia

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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