Systematic reviews in hematopoietic cell transplantation and cellular therapy: considerations and guidance from the American Society for Transplantation and Cellular Therapy, European Society for Blood and Marrow Transplantation, and the Center for International Blood and Marrow Transplant Research late effects and quality of life working committee

Akshay Sharma, Sherif M. Badawy, Elizabeth M. Suelzer, Hemant S. Murthy, Pinki Prasad, Hesham Eissa, Paul A. Carpenter, Mehdi Hamadani, Myriam Labopin, Hélène Schoemans, André Tichelli, Rachel Phelan, Betty K. Hamilton, David Buchbinder, Annie Im, Rebecca Hunter, Ruta Brazauskas, Linda J. Burns*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Systematic reviews apply rigorous methodologies to address a pre-specified, clearly formulated clinical research question. The conclusion that results is often cited to more robustly inform decision-making by clinicians, third-party payers and managed care organizations about the clinical question of interest. While systematic reviews provide a rigorous standard, they may be unfeasible when the task is to create general disease-focused guidelines comprised of multiple clinical practice questions versus a single major clinical practice question. Collaborating transplantation and cellular therapy societal committees also recognize that the quantity and or quality of reference sources may be insufficient for a meaningful systematic review. As the conduct of systematic reviews has evolved over time in terms of grading systems, reporting requirements and use of technology, here we provide current guidance in methodologies, resources for reviewers, and approaches to overcome challenges in conducting systematic reviews in transplantation and cellular therapy.

Original languageEnglish (US)
Pages (from-to)786-797
Number of pages12
JournalBone Marrow Transplantation
Volume56
Issue number4
DOIs
StatePublished - Apr 2021

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint

Dive into the research topics of 'Systematic reviews in hematopoietic cell transplantation and cellular therapy: considerations and guidance from the American Society for Transplantation and Cellular Therapy, European Society for Blood and Marrow Transplantation, and the Center for International Blood and Marrow Transplant Research late effects and quality of life working committee'. Together they form a unique fingerprint.

Cite this