Systematic Reviews in Hematopoietic Cell Transplantation and Cellular Therapy: Considerations and Guidance from the American Society for Transplantation and Cellular Therapy, European Society for Blood and Marrow Transplantation, and Center for International Blood and Marrow Transplant Research Late Effects and Quality of Life Working Committee

Akshay Sharma, Sherif M. Badawy, Elizabeth M. Suelzer, Hemant S. Murthy, Pinki Prasad, Hesham Eissa, Paul A. Carpenter, Mehdi Hamadani, Myriam Labopin, Hélène Schoemans, André Tichelli, Rachel Phelan, Betty K. Hamilton, David Buchbinder, Annie Im, Rebecca Hunter, Ruta Brazauskas, Linda J. Burns*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Systematic reviews apply rigorous methodologies to address a prespecified, clearly formulated clinical research question. The conclusion that results is often cited to more robustly inform decision making by clinicians, third-party payers, and managed care organizations about the clinical question of interest. Although systematic reviews provide a rigorous standard, they may be infeasible when the task is to create general disease-focused guidelines comprising multiple clinical practice questions versus a single major clinical practice question. Collaborating transplantation and cellular therapy society committees also recognize that the quantity and or quality of reference sources may be insufficient for a meaningful systematic review. As the conduct of systematic reviews has evolved over time in terms of grading systems, reporting requirements, and use of technology, here we provide current guidance on methodologies, resources for reviewers, and approaches to overcome challenges in conducting systematic reviews in transplantation and cellular therapy.

Original languageEnglish (US)
Pages (from-to)380-388
Number of pages9
JournalTransplantation and Cellular Therapy
Volume27
Issue number5
DOIs
StatePublished - May 2021

Keywords

  • Cellular therapy
  • Hematopoietic cell transplantation
  • Systematic reviews

ASJC Scopus subject areas

  • Hematology
  • Transplantation
  • Immunology and Allergy
  • Cell Biology
  • Molecular Medicine
  • Medicine(all)

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