Systemic and central amygdala injections of the mGluR2/3 agonist LY379268 attenuate the expression of incubation of sucrose craving in rats

Jamie L. Uejima, Jennifer M. Bossert, Gabriela C. Poles, Lin Lu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

We previously reported that systemic or central amygdala injections of the mGluR2/3 agonist LY379268 (which decreases glutamate release) prevented enhanced cue-induced cocaine seeking in extinction tests after prolonged withdrawal (incubation of cocaine craving). Here, we report that systemic and central amygdala injections of LY379268 also prevented the enhanced cue-induced sucrose seeking in extinction tests after prolonged sucrose-free period (incubation of sucrose craving). These findings suggest that central amygdala glutamate plays an important role in the incubation of reward craving after withdrawal from both drug and non-drug rewards.

Original languageEnglish (US)
Pages (from-to)292-296
Number of pages5
JournalBehavioural Brain Research
Volume181
Issue number2
DOIs
StatePublished - Aug 6 2007

Keywords

  • Central amygdala
  • Food reward
  • Glutamate
  • Incubation of craving
  • Relapse
  • Sucrose

ASJC Scopus subject areas

  • Behavioral Neuroscience

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