Systemic and central amygdala injections of the mGluR2/3 agonist LY379268 attenuate the expression of incubation of sucrose craving in rats

Jamie L. Uejima; Jennifer M. Bossert; Gabriela C. Poles; Lin Lu

doi:10.1016/j.bbr.2007.04.019

Systemic and central amygdala injections of the mGluR_2/3 agonist LY379268 attenuate the expression of incubation of sucrose craving in rats

Jamie L. Uejima, Jennifer M. Bossert, Gabriela C. Poles, Lin Lu^*

^*Corresponding author for this work

Anesthesiology

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

We previously reported that systemic or central amygdala injections of the mGluR_2/3 agonist LY379268 (which decreases glutamate release) prevented enhanced cue-induced cocaine seeking in extinction tests after prolonged withdrawal (incubation of cocaine craving). Here, we report that systemic and central amygdala injections of LY379268 also prevented the enhanced cue-induced sucrose seeking in extinction tests after prolonged sucrose-free period (incubation of sucrose craving). These findings suggest that central amygdala glutamate plays an important role in the incubation of reward craving after withdrawal from both drug and non-drug rewards.

Original language	English (US)
Pages (from-to)	292-296
Number of pages	5
Journal	Behavioural Brain Research
Volume	181
Issue number	2
DOIs	https://doi.org/10.1016/j.bbr.2007.04.019
State	Published - Aug 6 2007

Keywords

Central amygdala
Food reward
Glutamate
Incubation of craving
Relapse
Sucrose

ASJC Scopus subject areas

Behavioral Neuroscience

Access to Document

10.1016/j.bbr.2007.04.019

Cite this

@article{19a6b749430647f7982e282b187e346e,

title = "Systemic and central amygdala injections of the mGluR2/3 agonist LY379268 attenuate the expression of incubation of sucrose craving in rats",

abstract = "We previously reported that systemic or central amygdala injections of the mGluR2/3 agonist LY379268 (which decreases glutamate release) prevented enhanced cue-induced cocaine seeking in extinction tests after prolonged withdrawal (incubation of cocaine craving). Here, we report that systemic and central amygdala injections of LY379268 also prevented the enhanced cue-induced sucrose seeking in extinction tests after prolonged sucrose-free period (incubation of sucrose craving). These findings suggest that central amygdala glutamate plays an important role in the incubation of reward craving after withdrawal from both drug and non-drug rewards.",

keywords = "Central amygdala, Food reward, Glutamate, Incubation of craving, Relapse, Sucrose",

author = "Uejima, {Jamie L.} and Bossert, {Jennifer M.} and Poles, {Gabriela C.} and Lin Lu",

note = "Funding Information: This research was supported by funds from the Intramural Research Program of the NIH, the National Institute on Drug Abuse to the Neurobiology of Relapse Section (PI. Yavin Shaham). We thank Eli Lilly for providing LY379268, and Dr. Yavin Shaham for his help in the preparation of this manuscript. ",

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AU - Uejima, Jamie L.

AU - Bossert, Jennifer M.

AU - Poles, Gabriela C.

AU - Lu, Lin

N1 - Funding Information: This research was supported by funds from the Intramural Research Program of the NIH, the National Institute on Drug Abuse to the Neurobiology of Relapse Section (PI. Yavin Shaham). We thank Eli Lilly for providing LY379268, and Dr. Yavin Shaham for his help in the preparation of this manuscript.

PY - 2007/8/6

Y1 - 2007/8/6

N2 - We previously reported that systemic or central amygdala injections of the mGluR2/3 agonist LY379268 (which decreases glutamate release) prevented enhanced cue-induced cocaine seeking in extinction tests after prolonged withdrawal (incubation of cocaine craving). Here, we report that systemic and central amygdala injections of LY379268 also prevented the enhanced cue-induced sucrose seeking in extinction tests after prolonged sucrose-free period (incubation of sucrose craving). These findings suggest that central amygdala glutamate plays an important role in the incubation of reward craving after withdrawal from both drug and non-drug rewards.

AB - We previously reported that systemic or central amygdala injections of the mGluR2/3 agonist LY379268 (which decreases glutamate release) prevented enhanced cue-induced cocaine seeking in extinction tests after prolonged withdrawal (incubation of cocaine craving). Here, we report that systemic and central amygdala injections of LY379268 also prevented the enhanced cue-induced sucrose seeking in extinction tests after prolonged sucrose-free period (incubation of sucrose craving). These findings suggest that central amygdala glutamate plays an important role in the incubation of reward craving after withdrawal from both drug and non-drug rewards.

KW - Central amygdala

KW - Food reward

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KW - Incubation of craving

KW - Relapse

KW - Sucrose

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