Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease

Patrick J. Gavin, Susan E. Crawford, Stanford T. Shulman, Francesca L. Garcia, Anne H. Rowley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Objective - Coronary artery aneurysms are the major complication of Kawasaki disease (KD). Matrix metalloproteinases (MMPs) regulate remodeling and degradation of the extracellular matrix. We hypothesized that MMP-9 expression is increased in acute KD aneurysms when compared with KD nonaneurysmal arteries and arteries from control children. Methods and Results - MMP-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1, and TIMP-2 were immunolocalized in coronary arteries from children with fatal acute KD and controls. In KD coronary aneurysms, MMP-2 expression was prominent in the thickened neointima and in endothelial cells of new capillaries in areas of angiogenesis. MMP-9 was absent in control coronary arteries but was expressed in coronary artery aneurysms, nonaneurysmal coronary and noncoronary arteries, and cardiac nerves in acute KD, without an increase in TIMP-1 expression. Conclusions - MMP-2 likely participates in remodeling of the arterial wall in acute KD, particularly in the processes of neointimal proliferation and angiogenesis. MMP-9 may play a role in the development of coronary aneurysms, but its expression is not confined to aneurysmal arteries. Systemic arterial expression of MMP-9 in acute KD, even in the absence of inflammatory changes in the vessel, suggests induction by a circulating factor, or possibly by an infectious agent with tropism for arterial tissue.

Original languageEnglish (US)
Pages (from-to)576-581
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Volume23
Issue number4
DOIs
StatePublished - Apr 1 2003

Keywords

  • Aneurysm
  • Coronary artery
  • Kawasaki disease
  • Matrix metalloproteinases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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