Systemic eosinophilic disease presenting as dacryoadenitis

Kayla Danesh, Liza M. Cohen, Yan Liu, Justin N. Karlin, Daniel B. Rootman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Eosinophilic disease with orbital involvement is rare. We present two patients with dacryoadenitis associated with local and systemic eosinophilia. A 32-year-old man presented with episodic dacryoadenitis, lower respiratory inflammation and peripheral eosinophilia. Lung and lacrimal gland biopsies demonstrated eosinophilic infiltrate without granuloma, necrosis, or vasculitis. He improved with oral corticosteroids and Mepolizumab, an IL-5 inhibitor. The second case involved a 33-year-old man who similarly presented with episodic dacryoadenitis, pulmonary inflammation and pain/swelling in the hands and feet. Lacrimal gland biopsy demonstrated a predominantly eosinophilic infiltrate without granuloma or vasculitis. Symptoms improved with oral corticosteroids. Although neither patient was provided a definitive diagnosis, both were determined to have an eosinophilic condition on the spectrum of eosinophilic asthma or eosinophilic granulomatosis with polyangiitis.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalOrbit (London)
Issue number1
StatePublished - 2023
Externally publishedYes


  • Dacryoadenitis
  • eosinophilia
  • eosinophilic asthma
  • eosinophilic granulomatosis with polyangiitis
  • orbit

ASJC Scopus subject areas

  • Ophthalmology


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