Systemic hemorrhage augments local O2 extraction in canine intestine

R. W. Samsel, P. T. Schumacker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

When O2 delivery (Q̇O2) to a tissue is reduced, microvascular adjustments facilitate increases in O2 extraction, thereby delaying the onset of O2 supply limited metabolism until a critically low Q̇O2 is reached. The present study investigated the contribution of the autonomic nervous system to these adjustments by measuring O2 extraction in isolated intestine. In anesthetized dogs, a 30- to 50-g segment of intestine was vascularly isolated and its Q̇O2 was decreased in stages by reducing the speed of an occlusive pump. In a normovolemic group (n = 11), blood volume was maintained to minimize sympathetic tone while flow to the intestine was reduced. In a hypovolemic group (n = 7), blood volume was removed in stages to augment sympathetic tone as flow to the intestinal segment was simultaneously reduced. A hypovolemic α-adrenergic-blocked (α-blocked) group (n = 6) was identical to the corresponding α-adrenergic intact (α- intact) group except that α-adrenergic effects were inhibited with phenoxybenzamine (3 mg/kg). The systemic critical O2 extraction ratio in the α-blocked group (69 ± 6%) was less than that in the α-intact group (77 ± 7%; P = 0.05). In the intestine, the critical O2 extraction ratio was significantly poorer in the normovolemic (45 ± 11%) group than in either hypovolemic group (α-intact: 69 ± 3%, P < 0.00005; α-blocked: 62 ± 9%, P < 0.005). These findings demonstrate that systemic hemorrhage significantly augments critical O2 extraction in intestine during progressive local stagnant hypoxia and suggest that nonadrenergic vasoconstrictor mechanisms may play an important role.

Original languageEnglish (US)
Pages (from-to)2291-2298
Number of pages8
JournalJournal of applied physiology
Volume77
Issue number5
DOIs
StatePublished - 1994

Keywords

  • blood flow
  • hypoxia
  • ischemia
  • microcirculation
  • oxygen consumption
  • oxygen delivery
  • phenoxybenzamine
  • sympathetic tone

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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