Evidence suggests that systemic inflammation increases due to HIV infection. C-reactive protein (CRP), IL-6, and TNF-α values were compared between HIV+ and HIV- young men who have sex with men and transgender women. CRP values were >3 mg/L among 49.8% of participants. HIV status was not significantly associated with CRP nor IL-6. TNF-α was significantly higher among HIV+ participants. These results suggest further study of causes and health consequences of elevated systemic inflammation among this population.