TY - JOUR
T1 - Systemic lupus erythematosus
T2 - a case-based presentation of renal, neurologic, and hematologic emergencies
AU - Campbell, Eric J.
AU - Clarke, Ann E.
AU - Ramsey-Goldman, Rosalind
N1 - Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/10/3
Y1 - 2018/10/3
N2 - Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with systemic manifestations and multiorgan involvement. Although primarily diagnosed, and managed in the outpatient setting, it can occasionally present with life-threatening complications that require rapid assessment and urgent aggressive therapy. Areas covered: In our review, we explore three organ systems that are often affected in SLE, but have the potential to present as medical emergencies; these are the kidney, the central nervous system, and the hematologic system. We take a case-based approach to each clinical scenario, with information given sequentially in order to reflect “real-life” situations where management decisions need to be made with limited information. We review the acute management, pathophysiology, diagnostic approach, and treatment along with a review of the literature, for lupus nephritis presenting as rapidly progressive glomerulonephritis, acute lupus transverse myelitis, and refractory antiphospholipid syndrome. Expert commentary: At the conclusion of each section, we provide an expert commentary regarding each issue, relating to diagnosis, early management, and current evidence behind treatment recommendations.
AB - Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with systemic manifestations and multiorgan involvement. Although primarily diagnosed, and managed in the outpatient setting, it can occasionally present with life-threatening complications that require rapid assessment and urgent aggressive therapy. Areas covered: In our review, we explore three organ systems that are often affected in SLE, but have the potential to present as medical emergencies; these are the kidney, the central nervous system, and the hematologic system. We take a case-based approach to each clinical scenario, with information given sequentially in order to reflect “real-life” situations where management decisions need to be made with limited information. We review the acute management, pathophysiology, diagnostic approach, and treatment along with a review of the literature, for lupus nephritis presenting as rapidly progressive glomerulonephritis, acute lupus transverse myelitis, and refractory antiphospholipid syndrome. Expert commentary: At the conclusion of each section, we provide an expert commentary regarding each issue, relating to diagnosis, early management, and current evidence behind treatment recommendations.
KW - Systemic lupus erythematosus
KW - acute transverse myelitis
KW - antiphospholipid syndrome
KW - lupus nephritis
KW - rapidly progressive glomerulonephritis
UR - http://www.scopus.com/inward/record.url?scp=85054661301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054661301&partnerID=8YFLogxK
U2 - 10.1080/1744666X.2018.1518132
DO - 10.1080/1744666X.2018.1518132
M3 - Review article
C2 - 30173578
AN - SCOPUS:85054661301
VL - 14
SP - 803
EP - 816
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 10
ER -