Systemic lupus erythematosus: a case-based presentation of renal, neurologic, and hematologic emergencies

Eric J. Campbell, Ann E. Clarke, Rosalind Ramsey-Goldman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with systemic manifestations and multiorgan involvement. Although primarily diagnosed, and managed in the outpatient setting, it can occasionally present with life-threatening complications that require rapid assessment and urgent aggressive therapy. Areas covered: In our review, we explore three organ systems that are often affected in SLE, but have the potential to present as medical emergencies; these are the kidney, the central nervous system, and the hematologic system. We take a case-based approach to each clinical scenario, with information given sequentially in order to reflect “real-life” situations where management decisions need to be made with limited information. We review the acute management, pathophysiology, diagnostic approach, and treatment along with a review of the literature, for lupus nephritis presenting as rapidly progressive glomerulonephritis, acute lupus transverse myelitis, and refractory antiphospholipid syndrome. Expert commentary: At the conclusion of each section, we provide an expert commentary regarding each issue, relating to diagnosis, early management, and current evidence behind treatment recommendations.

Original languageEnglish (US)
Pages (from-to)803-816
Number of pages14
JournalExpert Review of Clinical Immunology
Issue number10
StatePublished - Oct 3 2018


  • Systemic lupus erythematosus
  • acute transverse myelitis
  • antiphospholipid syndrome
  • lupus nephritis
  • rapidly progressive glomerulonephritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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